{"id":"W2113204284","doi":"10.1152/ajpgi.00280.2010","title":"Role of EP4 receptor and prostaglandin transporter in prostaglandin E<sub>2</sub>-induced alteration in colonic epithelial barrier integrity","year":2010,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Prostaglandin E2 receptor; Receptor; Prostaglandin E; Prostaglandin; Chemistry; Internal medicine; Prostaglandin E2; Proinflammatory cytokine; Intestinal mucosa; Endocrinology; Tight junction; Apical membrane; Cell biology; Biology; Inflammation; Biochemistry; Medicine; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004606671,0.0002473186,0.0009051393,0.0002932453,0.00003749317,0.000005672309,0.00008919667,0.00009590283,0.00002879649],"category_scores_gemma":[0.0001650216,0.0001864035,0.00009853643,0.0001870033,0.0007045997,0.0001399717,0.00003072405,0.001138476,0.000002472468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003585322,"about_ca_system_score_gemma":0.0002027148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001449344,"about_ca_topic_score_gemma":0.0001530754,"domain_scores_codex":[0.9983175,0.0002514203,0.0006424615,0.0003032491,0.0001268263,0.0003584988],"domain_scores_gemma":[0.9987463,0.000228099,0.0005282154,0.00013407,0.0001717642,0.000191527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003512481,0.0002269741,0.1015336,0.00008760001,0.00002368866,0.00003113665,0.0007954933,0.000002968827,0.8902288,0.00006334518,0.000006785169,0.003487133],"study_design_scores_gemma":[0.00237001,0.007195747,0.8080286,0.0002878417,0.00003635118,0.0006696116,0.0003511893,0.0003147894,0.1802611,0.0003270998,0.00001756458,0.0001401099],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993476,0.0000554223,0.000005982768,0.0001233996,0.0001055821,0.0003340959,0.00001528165,0.000006693729,0.000005926589],"genre_scores_gemma":[0.9987814,0.00007693125,0.000704616,0.00009972159,0.000288461,0.00001485317,0.00001519127,0.00001711887,0.000001742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7099677,"threshold_uncertainty_score":0.7601314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005320148057372806,"score_gpt":0.2224112792030205,"score_spread":0.2170911311456477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}