{"id":"W2113204284","doi":"10.1152/ajpgi.00280.2010","title":"Role of EP4 receptor and prostaglandin transporter in prostaglandin E<sub>2</sub>-induced alteration in colonic epithelial barrier integrity","year":2010,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Prostaglandin E2 receptor; Receptor; Prostaglandin E; Prostaglandin; Chemistry; Internal medicine; Prostaglandin E2; Proinflammatory cytokine; Intestinal mucosa; Endocrinology; Tight junction; Apical membrane; Cell biology; Biology; Inflammation; Biochemistry; Medicine; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215697,0.0003295841,0.0004646684,0.0004063892,0.0001663376,0.0003625005,0.0002438112,0.0007222356,0.002043202],"category_scores_gemma":[0.0002390212,0.0002420841,0.0005423953,0.000221904,0.0003283841,0.0005560921,0.0003088479,0.0005472526,0.0005147225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003807757,"about_ca_system_score_gemma":0.0002258791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004256007,"about_ca_topic_score_gemma":0.0002874706,"domain_scores_codex":[0.9997749,0.00007950151,0.00001771479,0.00002501833,0.00003460652,0.00006831585],"domain_scores_gemma":[0.9998528,0.00002281384,0.00004112664,0.00001749955,0.00002532917,0.00004035957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002089974,0.00008709988,0.003002687,0.0002807,0.00003763931,0.001539359,0.00004894134,0.0001197718,0.9872159,0.0005369672,0.0001584047,0.004882484],"study_design_scores_gemma":[0.0002456942,0.002742256,0.1414341,0.00005773671,0.0002731306,0.0053122,0.0004230474,0.004769031,0.8354783,0.0008728344,0.008353762,0.00003793832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780586,0.01254771,0.005650196,0.0005752858,0.00007819663,0.00009879655,0.000355064,0.0001302976,0.002505793],"genre_scores_gemma":[0.9882967,0.004459275,0.002640684,0.0001935958,0.00005550067,0.000113852,0.0003199929,0.00001661058,0.003903776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002043202,"threshold_uncertainty_score":0.006835163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005320148057372806,"score_gpt":0.2224112792030205,"score_spread":0.2170911311456477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}