{"id":"W2113224775","doi":"10.1073/pnas.0805685105","title":"Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Institutes of Health; Howard Hughes Medical Institute","keywords":"Proliferating cell nuclear antigen; Biology; Ubiquitin; Cell biology; Genome instability; DNA damage; DNA replication; Postreplication repair; DNA repair; Mutagenesis; DNA; Genetics; Mutation; Gene; Nucleotide excision repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006470924,0.00006463272,0.00009676786,0.00003520418,0.0001241832,0.000006886869,0.0003064071,0.00009053156,0.000003950942],"category_scores_gemma":[0.0002581408,0.00005217968,0.00003789745,0.0001224404,0.0003261177,0.00003001349,0.0001484672,0.00005448044,1.302703e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001289111,"about_ca_system_score_gemma":0.00002944579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009468199,"about_ca_topic_score_gemma":6.394303e-8,"domain_scores_codex":[0.9989909,0.000009320077,0.0002665775,0.0002741031,0.0003798468,0.00007927132],"domain_scores_gemma":[0.9993507,0.00001528213,0.000433344,0.00001829339,0.0001616276,0.00002080701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001913599,0.00004462697,0.009118055,0.00002454553,0.000006750252,6.244461e-10,0.0001446442,0.000006693005,0.9899785,0.0003747179,0.0001000541,0.0001822969],"study_design_scores_gemma":[0.0001610486,0.0000763695,0.04052804,0.00001627716,0.000004246168,0.000001776571,0.00008785273,0.0007117917,0.9555045,0.002784607,0.00007412923,0.00004930567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987051,0.0001232456,0.000007911864,0.0001731141,0.000005384841,0.0002274592,0.00003420841,0.000003991094,0.0007195161],"genre_scores_gemma":[0.9968803,0.00007389183,0.002909903,0.00005765512,0.00002372065,0.000006022518,0.000002362705,0.000004430527,0.00004170747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03447392,"threshold_uncertainty_score":0.2127826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014182458921602,"score_gpt":0.2622038174203239,"score_spread":0.2420619928311079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}