{"id":"W2113242315","doi":"10.1136/jmg.37.11.817","title":"Multiple endocrine neoplasia type 2 and<i>RET</i>: from neoplasia to neurogenesis","year":2000,"lang":"en","type":"review","venue":"Journal of Medical Genetics","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Multiple endocrine neoplasia type 2; Multiple endocrine neoplasia; Carcinogenesis; Proto-Oncogene Proteins c-ret; Cancer research; Germline mutation; Biology; Mutation; Cancer; Receptor tyrosine kinase; Medullary thyroid cancer; MEN1; Pheochromocytoma; Germline; Medullary carcinoma; Tyrosine kinase; Thyroid carcinoma; Genetics; Endocrinology; Gene; Thyroid cancer; Thyroid; Kinase; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000315652,0.0007123533,0.0009233904,0.001626113,0.0002669758,0.0007147572,0.0007022872,0.001034268,0.002793056],"category_scores_gemma":[0.0004065039,0.0002028185,0.0002136914,0.001614557,0.0003645183,0.001061206,0.0003991718,0.0009987644,0.003332959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005560367,"about_ca_system_score_gemma":0.0005926286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009612935,"about_ca_topic_score_gemma":0.002107389,"domain_scores_codex":[0.9998987,0.00001213746,0.0000162568,0.00001859939,0.00004442341,0.000009929516],"domain_scores_gemma":[0.9998486,0.0000534868,0.00001770272,0.000004874524,0.00004752027,0.00002771695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000774176,0.00004693958,0.000226505,0.005874038,0.00003583475,0.0008794603,0.00006551494,0.0002335915,0.003142488,0.002101992,0.04100379,0.9463124],"study_design_scores_gemma":[0.00001513682,0.00005749715,0.001000853,0.0008693779,0.00003305309,0.003735041,0.00005724673,0.00003462772,0.0006529802,0.0009770102,0.9925575,0.000009590465],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002664635,0.9964149,0.0001947935,0.000344011,0.0004539068,0.000005107223,0.00001647749,0.00001333227,0.002291065],"genre_scores_gemma":[0.001032047,0.9955069,0.0003493189,0.0003577723,0.0002957518,0.000008481132,0.00003639202,0.000002726823,0.002410649],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002793056,"threshold_uncertainty_score":0.009343684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03621928832700033,"score_gpt":0.3347894568658241,"score_spread":0.2985701685388237,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}