{"id":"W2113262521","doi":"10.3109/10428194.2011.576791","title":"Bone marrow stromal cells protect myeloma cells from bortezomib induced apoptosis by suppressing microRNA-15a expression","year":2011,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Tianjin Science and Technology Program; Natural Science Foundation of Tianjin City; National Natural Science Foundation of China; Peking Union Medical College; Academy of Medical Sciences","keywords":"Bortezomib; Stromal cell; Multiple myeloma; Bone marrow; microRNA; Cancer research; Transfection; Apoptosis; Vascular endothelial growth factor; Medicine; Immunology; Chemistry; Biology; Cell culture; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001649842,0.0002197412,0.0003109329,0.0001907646,0.0001725339,0.0003250244,0.00009387651,0.0001623407,0.001435235],"category_scores_gemma":[0.00009347712,0.0001514021,0.0002653446,0.0001458581,0.0001480759,0.0001012556,0.0001995306,0.000431562,0.0003038563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001552991,"about_ca_system_score_gemma":0.0002777702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005125246,"about_ca_topic_score_gemma":0.001233897,"domain_scores_codex":[0.999881,0.00002259693,0.00001576679,0.00001966638,0.0000347669,0.00002618194],"domain_scores_gemma":[0.9999439,0.00001003009,0.0000182857,0.000005566594,0.000008769332,0.00001349611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608283,0.00002791601,0.0002962112,0.00003861866,0.00001173746,0.00002818362,0.0000166637,0.00003191927,0.9971514,0.00006496667,0.00006885427,0.002102746],"study_design_scores_gemma":[0.00005628413,0.0005515742,0.006310684,0.000008726161,0.00003305588,0.0001989031,0.00005024792,0.0005282584,0.9868024,0.00005862343,0.005396893,0.000004355657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915634,0.004261719,0.002027605,0.0002033822,0.00006597385,0.00003859168,0.0004037043,0.0001059307,0.001329667],"genre_scores_gemma":[0.993152,0.001753783,0.00228035,0.0001169955,0.00001767187,0.00004585895,0.0006726602,0.00001450046,0.001946292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001435235,"threshold_uncertainty_score":0.004801273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02094314562739251,"score_gpt":0.2422504560969769,"score_spread":0.2213073104695844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}