{"id":"W2113264717","doi":"10.1093/carcin/bgq034","title":"Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Irinotecan; Senescence; Colorectal cancer; Cysteine; Cancer research; Cellular senescence; Internal medicine; Chemistry; Biology; Medicine; Oncology; Cancer; Biochemistry; Enzyme; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003290103,0.0002043516,0.0002197108,0.0002401108,0.00003381171,0.00001923983,0.0001783079,0.0002155553,0.00001425415],"category_scores_gemma":[0.0002175866,0.0002107555,0.00003236267,0.0005580368,0.00007571896,0.000006405002,0.0001194096,0.000181033,0.000005598923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001843337,"about_ca_system_score_gemma":0.0004002785,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01139451,"about_ca_topic_score_gemma":0.03758835,"domain_scores_codex":[0.9983654,0.0001797381,0.0002308676,0.0005626098,0.0001881587,0.000473213],"domain_scores_gemma":[0.9993845,0.0000250117,0.00004008937,0.0002753965,0.00005207802,0.0002229264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001594989,0.00004681907,0.1456433,0.00001660511,0.00001156512,0.00009770674,0.0002077027,0.000002871454,0.851751,3.313235e-7,0.00004367314,0.0005833978],"study_design_scores_gemma":[0.001776377,0.0005157004,0.111503,0.00002678616,0.000003479415,0.000005548383,0.00008331636,0.0000625716,0.8855536,0.00000214678,0.0002716265,0.0001958489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980049,0.0006387217,0.000004832025,0.0003525167,0.00004275392,0.0008234331,0.000103486,0.000007398368,0.00002198183],"genre_scores_gemma":[0.9992577,0.00005635588,0.00003947185,0.00009226536,0.00002685764,0.0003641181,0.00007326475,0.00002676238,0.00006321778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03414031,"threshold_uncertainty_score":0.9951887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007671073772907482,"score_gpt":0.2528387562745872,"score_spread":0.2451676825016797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}