{"id":"W2113264717","doi":"10.1093/carcin/bgq034","title":"Secreted protein acidic and rich in cysteine-induced cellular senescence in colorectal cancers in response to irinotecan is mediated by P53","year":2010,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"Irinotecan; Senescence; Colorectal cancer; Cysteine; Cancer research; Cellular senescence; Internal medicine; Chemistry; Biology; Medicine; Oncology; Cancer; Biochemistry; Enzyme; Phenotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001291405,0.0001882632,0.0002070847,0.0002719629,0.0001180746,0.000150414,0.00005970784,0.0001864482,0.0008139539],"category_scores_gemma":[0.0001261082,0.0001146796,0.0001853376,0.0001735534,0.0001492005,0.0001162084,0.0001114162,0.0003039901,0.0001253955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146197,"about_ca_system_score_gemma":0.0001249209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002756308,"about_ca_topic_score_gemma":0.0004175464,"domain_scores_codex":[0.9999146,0.0000197378,0.000009639271,0.00001315249,0.00002349866,0.00001928966],"domain_scores_gemma":[0.9999104,0.00001140556,0.00002738147,0.00001058151,0.00001162866,0.00002860084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977906,0.00001553506,0.0004035844,0.00002520818,0.00000528256,0.00006741587,0.000007293403,0.00002765571,0.9983216,0.00002640963,0.00001853901,0.0008838014],"study_design_scores_gemma":[0.00003125132,0.001116501,0.05107555,0.000005535516,0.00003305945,0.001622978,0.00003529452,0.0007778384,0.9433171,0.00007430642,0.001905053,0.000005424083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971488,0.001809411,0.0004728118,0.00006470946,0.00001055813,0.00001012845,0.00008903976,0.00002543205,0.0003691094],"genre_scores_gemma":[0.9979451,0.0007234178,0.0004485963,0.00002981034,0.000005815665,0.00001147994,0.0001728638,0.00000409829,0.0006588196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008139539,"threshold_uncertainty_score":0.002722979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007671073772907482,"score_gpt":0.2528387562745872,"score_spread":0.2451676825016797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}