{"id":"W2113270134","doi":"10.1016/j.molbiopara.2009.05.002","title":"RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs","year":2009,"lang":"en","type":"article","venue":"Molecular and Biochemical Parasitology","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; U.S. Public Health Service; Universidad de la República Uruguay","keywords":"Biology; RNA interference; Schistosoma mansoni; Schistosoma japonicum; Gene knockdown; Gene; RNA; Molecular biology; Genetics; Helminths; Schistosomiasis; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006957094,0.0001937217,0.0003583026,0.00009642643,0.0001015098,0.000009644054,0.000176218,0.0002651396,0.0001190008],"category_scores_gemma":[0.00008768634,0.0001735832,0.000103268,0.0000908943,0.0002420853,0.00004272954,0.00006092127,0.0003595699,0.0000358855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001546047,"about_ca_system_score_gemma":0.00001854123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000946457,"about_ca_topic_score_gemma":0.000003047724,"domain_scores_codex":[0.9988771,0.00007955723,0.000340971,0.0003522435,0.00002838265,0.0003217497],"domain_scores_gemma":[0.9995135,0.0000685069,0.0001228219,0.0001958483,0.00005582825,0.00004348281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001458898,0.0001333023,0.002311229,0.000009674039,0.00006782339,0.00002548395,0.0001446689,0.00000185253,0.9924017,0.001129652,0.001119628,0.002509098],"study_design_scores_gemma":[0.0006179576,0.0003266741,0.004771745,0.00004944838,0.0000540011,0.0002477705,0.00006831354,0.00001433833,0.9916251,0.000446253,0.001587044,0.0001913079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905366,0.004805464,0.001424722,0.0007903029,0.0001804959,0.00009684978,0.00001255262,0.000038105,0.002114912],"genre_scores_gemma":[0.9988616,0.00004694375,0.0003943999,0.0003765341,0.00002073282,0.000004361098,0.00007664596,0.000007657507,0.0002111497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008324979,"threshold_uncertainty_score":0.7078517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007186585606668141,"score_gpt":0.2897581406644584,"score_spread":0.2825715550577902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}