{"id":"W2113322063","doi":"10.1371/journal.pone.0026778","title":"Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deutsche Nierenstiftung; Deutsche Forschungsgemeinschaft","keywords":"Inflammasome; Caspase 1; Inflammation; Proinflammatory cytokine; Nephritis; Glomerulonephritis; Immunology; Lupus nephritis; Interleukin 17; Biology; Endocrinology; Medicine; Internal medicine; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829695,0.0005101949,0.0003608715,0.0004878199,0.0001354528,0.0003899409,0.0002168653,0.0002941304,0.001906868],"category_scores_gemma":[0.0001677832,0.000166779,0.0004721293,0.0001862717,0.0003955846,0.0004078806,0.0002662072,0.0008940962,0.0005245826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002732294,"about_ca_system_score_gemma":0.000223065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003213596,"about_ca_topic_score_gemma":0.0004371458,"domain_scores_codex":[0.9996523,0.00005066067,0.00003865656,0.00006565852,0.0001106106,0.00008216329],"domain_scores_gemma":[0.9997589,0.00001306049,0.00009667757,0.00003587521,0.00003793502,0.0000576092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004896602,0.00007412744,0.001235172,0.0001945282,0.00002330571,0.0002033248,0.00003432955,0.00003486411,0.9928132,0.0002242375,0.0001269193,0.004546322],"study_design_scores_gemma":[0.0001166037,0.001274232,0.07670384,0.00007197055,0.0001233001,0.003771899,0.00008640519,0.001024371,0.9040123,0.0004169446,0.01238586,0.00001234719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98128,0.008432871,0.004562513,0.0003516151,0.00009901774,0.00008165051,0.000719841,0.0003914585,0.004081145],"genre_scores_gemma":[0.9942531,0.001499242,0.001241476,0.00009402299,0.00002287796,0.00003398918,0.0003960496,0.00001612479,0.002443166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001906868,"threshold_uncertainty_score":0.006379128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855136071319707,"score_gpt":0.2028499782991964,"score_spread":0.1742986175859993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}