{"id":"W2113322063","doi":"10.1371/journal.pone.0026778","title":"Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Deutsche Nierenstiftung; Deutsche Forschungsgemeinschaft","keywords":"Inflammasome; Caspase 1; Inflammation; Proinflammatory cytokine; Nephritis; Glomerulonephritis; Immunology; Lupus nephritis; Interleukin 17; Biology; Endocrinology; Medicine; Internal medicine; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241458,0.0001775591,0.0003250945,0.0001177677,0.00003968892,0.000005867621,0.0002108685,0.0002375463,0.0001600163],"category_scores_gemma":[0.0001359843,0.0001883543,0.0001060474,0.0001618576,0.0001377933,0.00001760032,0.0001183199,0.0001132064,0.00001811243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001020711,"about_ca_system_score_gemma":0.00008205676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002588708,"about_ca_topic_score_gemma":0.00003037644,"domain_scores_codex":[0.9987301,0.00004705079,0.0004296446,0.0002656108,0.0002860913,0.0002415559],"domain_scores_gemma":[0.9989516,0.00001266079,0.000283052,0.0004156102,0.0002828639,0.00005427753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511729,0.0007330917,0.02586379,0.0001740965,0.0004066968,0.0000018934,0.0005907809,8.172109e-7,0.9714305,0.00002914272,0.0001006858,0.0005173701],"study_design_scores_gemma":[0.0009155624,0.0003817751,0.04072307,0.0001005567,0.00006685972,0.000001016516,0.0003814305,0.00001251577,0.9569865,0.00005615148,0.0001774285,0.0001971024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971837,0.0005518247,0.00003131218,0.00004701305,0.00003411667,0.0002568212,0.00009882851,0.00001293863,0.001783389],"genre_scores_gemma":[0.9977147,0.001166481,0.000409233,0.0001085086,0.00005203694,0.00002359814,0.0002752342,0.00002802325,0.0002221934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01485928,"threshold_uncertainty_score":0.7680866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02855136071319707,"score_gpt":0.2028499782991964,"score_spread":0.1742986175859993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}