{"id":"W2113336815","doi":"10.1186/1475-2867-7-14","title":"Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation","year":2007,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; McMaster University; Hamilton Regional Laboratory Medicine Program; BC Cancer Agency; Princess Margaret Cancer Centre; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"Terry Fox Foundation; National Cancer Institute; King Faisal Specialist Hospital and Research Centre","keywords":"Decitabine; Osteosarcoma; In vitro; Cancer research; Apoptosis; Gene; Gene expression; Demethylation; Identification (biology); Cell biology; Medicine; Biology; Genetics; DNA methylation; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003185661,0.00007325583,0.0001124278,0.0001020767,0.00001024591,0.000004114726,0.00006209802,0.00008705718,0.000003831705],"category_scores_gemma":[0.00004222887,0.00007930143,0.00002508506,0.00005918017,0.00004021933,0.00001365819,0.00002475738,0.00002317532,3.427166e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000231607,"about_ca_system_score_gemma":0.00001973937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001418285,"about_ca_topic_score_gemma":0.00005875598,"domain_scores_codex":[0.9991685,0.00002281753,0.0004315812,0.000182334,0.000116758,0.00007797622],"domain_scores_gemma":[0.9993981,0.00003796747,0.0002772783,0.00007391782,0.0001903303,0.00002247251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002732041,0.00006235398,0.02298407,0.00006193638,0.000008533504,5.831996e-8,0.0001007049,0.0004266044,0.9724067,0.00001389591,0.000004307095,0.003657635],"study_design_scores_gemma":[0.0007818514,0.00006281007,0.03419601,0.00001871452,0.000006544738,1.365966e-7,0.00004059012,0.00184885,0.9626613,0.0002722393,0.00004707319,0.00006387357],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9611416,0.005109754,0.03328792,0.00001572669,0.0001117411,0.0002182293,0.00007933984,9.869638e-7,0.00003471303],"genre_scores_gemma":[0.9944103,0.001234368,0.003990025,0.000005415086,0.00004051801,0.00001849734,0.0002667381,0.000008905391,0.00002525805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03326868,"threshold_uncertainty_score":0.3233819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007303904252595368,"score_gpt":0.2669877827120579,"score_spread":0.2596838784594626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}