{"id":"W2113336815","doi":"10.1186/1475-2867-7-14","title":"Modulation by decitabine of gene expression and growth of osteosarcoma U2OS cells in vitro and in xenografts: Identification of apoptotic genes as targets for demethylation","year":2007,"lang":"en","type":"article","venue":"Cancer Cell International","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; McMaster University; Hamilton Regional Laboratory Medicine Program; BC Cancer Agency; Princess Margaret Cancer Centre; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"Terry Fox Foundation; National Cancer Institute; King Faisal Specialist Hospital and Research Centre","keywords":"Decitabine; Osteosarcoma; In vitro; Cancer research; Apoptosis; Gene; Gene expression; Demethylation; Identification (biology); Cell biology; Medicine; Biology; Genetics; DNA methylation; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000126985,0.0002463427,0.0003248779,0.0002168949,0.00015269,0.0002369667,0.0001239841,0.0001935237,0.001070322],"category_scores_gemma":[0.0001104597,0.0001234346,0.0001570237,0.0002446019,0.0001579704,0.0001453185,0.0001159714,0.0003696018,0.0002568217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003300665,"about_ca_system_score_gemma":0.0001593601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009637264,"about_ca_topic_score_gemma":0.002012821,"domain_scores_codex":[0.9998937,0.00001649926,0.00001171246,0.00002456235,0.00003172152,0.00002182104],"domain_scores_gemma":[0.9999082,0.00002067354,0.00002368616,0.00001383521,0.00001440095,0.0000191098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001271747,0.00002438742,0.0002064394,0.00001245702,0.00000194633,0.000007826614,0.00001086841,0.00002862095,0.9990541,0.000008044557,0.00001081299,0.0005073745],"study_design_scores_gemma":[0.000007571216,0.0003329118,0.007515447,0.000001610574,0.000007268215,0.0000450215,0.00002980866,0.0004035695,0.9911653,0.000009365473,0.0004803725,0.000001699922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962555,0.001181777,0.001315023,0.00004392966,0.00001186004,0.00002369358,0.0004784505,0.00003646193,0.0006532761],"genre_scores_gemma":[0.9938762,0.0007664819,0.002489418,0.00003359093,0.0000050946,0.0000820286,0.0007315503,0.00001388784,0.002001851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070322,"threshold_uncertainty_score":0.00358057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007303904252595368,"score_gpt":0.2669877827120579,"score_spread":0.2596838784594626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}