{"id":"W2113382133","doi":"10.1200/jco.2008.20.7019","title":"Pathologic Complete Response Rates in Young Women With <i>BRCA1</i>-Positive Breast Cancers After Neoadjuvant Chemotherapy","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":507,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital","funders":"","keywords":"Medicine; Cyclophosphamide; Chemotherapy; Docetaxel; Oncology; Breast cancer; Regimen; Fluorouracil; Internal medicine; Doxorubicin; Neoadjuvant therapy; Cisplatin; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009654487,0.00009619254,0.0002934386,0.0005918728,0.0001203308,0.0002044246,0.0001343527,0.0002926808,0.000639589],"category_scores_gemma":[0.006059747,0.0001306558,0.0002191662,0.0002996526,0.0001588625,0.0002189693,0.0001689972,0.0001831752,0.000185105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794441,"about_ca_system_score_gemma":0.0001443262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006716896,"about_ca_topic_score_gemma":0.0008482828,"domain_scores_codex":[0.999359,0.0002526561,0.00006964204,0.0001040391,0.0001512041,0.00006350185],"domain_scores_gemma":[0.9967134,0.001284935,0.0014955,0.0001326975,0.0002043964,0.0001690587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003083231,0.00001495206,0.9943454,0.00001380175,0.00001947922,0.0001605296,0.0000491735,0.0001259973,0.0004894299,0.000006642881,0.00008938398,0.004376933],"study_design_scores_gemma":[0.00001454474,0.0003566782,0.9963413,0.000007648291,0.00002718491,0.00187872,0.00006662988,0.0002782044,0.0007279429,0.0000136118,0.000283219,0.000004298518],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987952,0.0005957063,0.0001405357,0.00002701051,0.000002929304,0.0000119335,0.0002104786,0.0000048851,0.000211336],"genre_scores_gemma":[0.9992985,0.0001641235,0.00008576651,0.00002105634,0.000007560336,0.00001428481,0.0003108004,0.000002427875,0.00009549768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009654487,"threshold_uncertainty_score":0.005105853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700909000413729,"score_gpt":0.3800088697682325,"score_spread":0.3529997797640952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}