{"id":"W2113415037","doi":"10.1007/3-540-29715-4_11","title":"Mutation-Specific Pharmacology of the Long QT Syndrome","year":2006,"lang":"en","type":"review","venue":"Handbook of experimental pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Columbia College","funders":"National Heart, Lung, and Blood Institute","keywords":"Long QT syndrome; Disease; Medicine; Short QT syndrome; Mutation; Bioinformatics; Genetics; Neuroscience; QT interval; Internal medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001283698,0.0004925464,0.002582312,0.0002428381,0.0001042714,0.000002937955,0.0002957936,0.0004483087,0.001635162],"category_scores_gemma":[0.000004335827,0.0003545296,0.001273745,0.0003195092,0.0008762185,0.00004407596,0.0001961556,0.0006523601,0.00006242334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137196,"about_ca_system_score_gemma":0.0003885982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001092664,"about_ca_topic_score_gemma":3.243123e-7,"domain_scores_codex":[0.9973675,0.0004452192,0.001018237,0.0004994188,0.0002320373,0.0004375754],"domain_scores_gemma":[0.9984376,0.0002637654,0.0007911955,0.0003228305,0.00008701939,0.00009757037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001660284,0.004254191,0.00002126732,0.02275654,0.00860443,0.01300439,0.0004790231,0.00004902165,0.6260118,0.0003408379,0.1707935,0.1520247],"study_design_scores_gemma":[0.00340684,0.001036833,0.00002693598,0.003707366,0.003531409,0.01284864,0.00002034985,0.000003384693,0.4554829,0.00001312914,0.5194946,0.0004276694],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008177903,0.9862237,0.000008426801,0.00002930607,0.002635838,0.001854034,0.00005842515,0.0000309926,0.0009814026],"genre_scores_gemma":[0.01697271,0.9807599,0.00007563784,0.0002175852,0.0007035774,0.0003348825,0.0001421846,0.00007432563,0.0007192444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.348701,"threshold_uncertainty_score":0.9998907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02817922706264153,"score_gpt":0.362733672144951,"score_spread":0.3345544450823095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}