{"id":"W2113416428","doi":"10.1126/science.1241006","title":"Fine Tuning of Craniofacial Morphology by Distant-Acting Enhancers","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Alberta Bone and Joint Health Institute","funders":"National Institute of Dental and Craniofacial Research; National Human Genome Research Institute; Lawrence Berkeley National Laboratory; National Institute of General Medical Sciences; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; U.S. Department of Energy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ludwig Institute for Cancer Research","keywords":"Craniofacial; Morphology (biology); Enhancer; Biology; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002525006,0.00005320548,0.00006642841,0.00002930069,0.0001232196,0.00002825188,0.0002548567,0.00003958046,0.0001516413],"category_scores_gemma":[0.0001562983,0.00004730895,0.00002419806,0.0001808785,0.0005933499,0.000007200734,0.0001117273,0.00005414258,0.00001764504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008804908,"about_ca_system_score_gemma":0.0001143463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001399229,"about_ca_topic_score_gemma":0.00001615681,"domain_scores_codex":[0.9992482,0.0000168741,0.0001017207,0.0002218717,0.0001602775,0.0002510433],"domain_scores_gemma":[0.9996148,0.00001055813,0.000040371,0.000170848,0.00009250716,0.00007095307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004110651,0.000008481964,0.009042945,0.000003549757,0.000001907899,3.033516e-7,0.00004206625,0.000004182641,0.9843302,0.00001045039,0.000449764,0.006102073],"study_design_scores_gemma":[0.0001528545,0.0001201762,0.01053801,0.000006765461,0.000001312983,0.000003741841,0.0001087767,0.0001880448,0.9807876,0.00005718723,0.007940691,0.00009487104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961769,0.00005573868,0.001016257,0.0001154649,0.0001058896,0.00006838344,0.000004383771,0.00000353502,0.002453426],"genre_scores_gemma":[0.9992306,0.00002351514,0.000207801,0.00003107322,0.00004093201,0.000005138016,0.0000071351,0.000004008169,0.0004498517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007490927,"threshold_uncertainty_score":0.2186222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239358468625403,"score_gpt":0.2894660450031503,"score_spread":0.2770724603168963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}