{"id":"W2113416428","doi":"10.1126/science.1241006","title":"Fine Tuning of Craniofacial Morphology by Distant-Acting Enhancers","year":2013,"lang":"en","type":"article","venue":"Science","topic":"Cleft Lip and Palate Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Alberta Bone and Joint Health Institute","funders":"National Institute of Dental and Craniofacial Research; National Human Genome Research Institute; Lawrence Berkeley National Laboratory; National Institute of General Medical Sciences; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; U.S. Department of Energy; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ludwig Institute for Cancer Research","keywords":"Craniofacial; Morphology (biology); Enhancer; Biology; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374576,0.0002802858,0.0001948276,0.0002706946,0.0001200142,0.0002613076,0.00025959,0.0002373622,0.002274508],"category_scores_gemma":[0.0002007808,0.0001937973,0.0002632506,0.00008690287,0.0002836293,0.0001250261,0.0002788515,0.0004091246,0.0006087021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632323,"about_ca_system_score_gemma":0.0001086757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003606977,"about_ca_topic_score_gemma":0.0006753738,"domain_scores_codex":[0.9998668,0.000009457789,0.000007214373,0.00005964694,0.00003106205,0.00002562644],"domain_scores_gemma":[0.9998032,0.00006952101,0.00005264051,0.0000228717,0.00001574926,0.00003597475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002751712,0.000009449021,0.0006816857,0.00001358056,0.000002293795,0.00003525208,0.000007255063,0.00005615844,0.9974873,0.00009520376,0.00001273672,0.001571668],"study_design_scores_gemma":[0.00004375637,0.0002479469,0.0873975,0.00002805641,0.00003499512,0.001196373,0.00005856238,0.003986246,0.9017802,0.0003954007,0.004811941,0.00001895617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839315,0.001488898,0.01174498,0.00005202457,0.00001542929,0.00002424955,0.0003235726,0.0002110865,0.002208162],"genre_scores_gemma":[0.9921129,0.000410812,0.005051434,0.00005072737,0.00001056299,0.00001945494,0.0005278574,0.0000519347,0.001764304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002274508,"threshold_uncertainty_score":0.00760901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01239358468625403,"score_gpt":0.2894660450031503,"score_spread":0.2770724603168963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}