{"id":"W2113427005","doi":"10.1136/jmg.2004.022012","title":"Genetic polymorphism of <i>CYP1A2</i> increases the risk of myocardial infarction","year":2004,"lang":"en","type":"article","venue":"Journal of Medical Genetics","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Genotype; Odds ratio; CYP1A2; Confounding; Internal medicine; Genetics; Myocardial infarction; Biology; Confidence interval; Population; Allele; Restriction fragment length polymorphism; Tobacco smoke; Gastroenterology; Medicine; Cytochrome P450; Gene; Environmental health; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006363142,0.0001378985,0.0002833875,0.00006105896,0.00004810134,0.000006898454,0.0004272838,0.0002266158,0.00004550463],"category_scores_gemma":[0.0002924172,0.00009168435,0.0003294017,0.0001198949,0.0003152166,0.000002877771,0.00006680093,0.0002631002,0.000001385473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009981694,"about_ca_system_score_gemma":0.0004585303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001971953,"about_ca_topic_score_gemma":0.00002953149,"domain_scores_codex":[0.9979802,0.000154486,0.0007224021,0.0001151015,0.0008532497,0.00017456],"domain_scores_gemma":[0.9988298,0.00005449205,0.0004485399,0.0002658101,0.000206618,0.0001947214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001428749,0.001531512,0.08661669,0.0001517755,0.002198333,0.000103247,0.0007806997,0.01682758,0.8290212,0.0006271524,0.003678045,0.057035],"study_design_scores_gemma":[0.01244661,0.007909393,0.298674,0.0004351086,0.001767845,0.002739914,0.0004991002,0.0001737057,0.6424854,0.003667143,0.02851272,0.0006890524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808255,0.01138588,0.006400453,0.0008644918,0.0003585611,0.00008311993,0.00002816094,0.000001671904,0.00005213836],"genre_scores_gemma":[0.9815931,0.01619043,0.001108985,0.0003386632,0.0007387938,0.000001341078,0.000004118659,0.00001650606,0.000008063742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2120573,"threshold_uncertainty_score":0.3738779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005900898820348689,"score_gpt":0.2328617741210335,"score_spread":0.2269608753006848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}