{"id":"W2113432767","doi":"10.1038/nature13108","title":"Epigenomic alterations define lethal CIMP-positive ependymomas of infancy","year":2014,"lang":"en","type":"article","venue":"Nature","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":622,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre; McMaster University; Hamilton General Hospital; Canada's Michael Smith Genome Sciences Centre; SickKids Foundation; BC Cancer Agency; Princess Margaret Cancer Centre; University of Toronto; University Health Network; University of British Columbia; Hospital for Sick Children; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Deutsche Krebshilfe; Pediatric Brain Tumor Foundation; Bundesministerium für Bildung und Forschung; Government of Ontario; Deutsches Krebsforschungszentrum; Deutschen Konsortium für Translationale Krebsforschung; Terry Fox Research Institute; CureSearch for Children's Cancer","keywords":"Biology; Epigenetics; DNA methylation; Atypical teratoid rhabdoid tumor; Genetics; CpG site; Cancer research; Methylation; Gene; Medulloblastoma; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006811452,0.0001019158,0.0002134742,0.00008119908,0.00004470396,0.000006787971,0.0000431526,0.0003483483,0.0001182525],"category_scores_gemma":[0.00009548602,0.0000784639,0.00009024541,0.0001100464,0.00002629411,0.0000328871,0.00001872052,0.0004714837,0.00004451167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002140189,"about_ca_system_score_gemma":0.0000311148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003913665,"about_ca_topic_score_gemma":0.00002790403,"domain_scores_codex":[0.9994001,0.00002538665,0.0001480244,0.0001550362,0.000143525,0.0001279417],"domain_scores_gemma":[0.9994596,0.00008907555,0.00006049043,0.0002155696,0.0001038533,0.00007139281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004893648,0.003686071,0.6398956,0.0002856506,0.001227798,0.0006185852,0.002250277,0.00009533726,0.1141418,0.1576803,0.03346183,0.04616749],"study_design_scores_gemma":[0.00291485,0.0005349902,0.8367033,0.0001465647,0.0002508591,0.0001646573,0.0000261813,0.000107639,0.1474335,0.0006926957,0.01088077,0.0001440403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820737,0.001613625,0.00005147848,0.002416173,0.0001574227,0.0002425496,0.00004293913,0.00002128666,0.01338081],"genre_scores_gemma":[0.997836,0.00002292045,0.001057835,0.000652824,0.0001479456,0.0000181382,0.0001160351,0.00001232699,0.0001359561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1968078,"threshold_uncertainty_score":0.3199665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006471429885891111,"score_gpt":0.267942884418207,"score_spread":0.2614714545323159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}