{"id":"W2113440807","doi":"10.1038/emboj.2011.204","title":"Autoregulation of Parkin activity through its ubiquitin‐like domain","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":351,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; Parkin; Ubiquitin; Autoregulation; Ubiquitin-Protein Ligases; Deubiquitinating enzyme; Ubiquitins; Cell biology; Domain (mathematical analysis); Ubiquitin ligase; Computational biology; Genetics; Gene; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001618445,0.0002576989,0.0001863837,0.0001462206,0.0001429823,0.0005521838,0.0002079356,0.0001865271,0.0007853658],"category_scores_gemma":[0.000172724,0.0001504834,0.0001665019,0.00009500427,0.0002620096,0.0003974974,0.0002585637,0.0004195743,0.0003395558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000550641,"about_ca_system_score_gemma":0.0001637875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003150741,"about_ca_topic_score_gemma":0.0008141912,"domain_scores_codex":[0.999908,0.00001489923,0.000008060681,0.00002773436,0.00001466261,0.0000266369],"domain_scores_gemma":[0.9998037,0.00004885626,0.00004696293,0.00004002207,0.00001460662,0.00004585823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409638,0.00002209962,0.0002299201,0.00001187554,0.000002740869,0.00004615325,0.000007398005,0.000121595,0.9972842,0.000522677,0.00004841508,0.00146204],"study_design_scores_gemma":[0.00001748554,0.00006153811,0.002734083,0.000001853626,0.000005766041,0.00008992816,0.00001325584,0.002039687,0.9939126,0.0001566802,0.0009625656,0.000004501664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915924,0.001267548,0.005378104,0.0001972522,0.00003848123,0.000007374965,0.0002050205,0.0001668683,0.00114689],"genre_scores_gemma":[0.9975165,0.0001693717,0.0008282057,0.00002452287,0.000008588167,0.000004176037,0.0001251825,0.00001908469,0.001304375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007853658,"threshold_uncertainty_score":0.00399524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.041463889186977,"score_gpt":0.2605403376875708,"score_spread":0.2190764485005938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}