{"id":"W2113440807","doi":"10.1038/emboj.2011.204","title":"Autoregulation of Parkin activity through its ubiquitin‐like domain","year":2011,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":351,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Biology; Parkin; Ubiquitin; Autoregulation; Ubiquitin-Protein Ligases; Deubiquitinating enzyme; Ubiquitins; Cell biology; Domain (mathematical analysis); Ubiquitin ligase; Computational biology; Genetics; Gene; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000552031,0.0001054397,0.0001136644,0.00001749043,0.0001457382,0.00001432719,0.0002407333,0.00007948568,0.0002038205],"category_scores_gemma":[0.00003276987,0.00007254937,0.0001068733,0.00005447485,0.0000820599,0.000009205243,0.00007493905,0.000160825,0.00001104163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000968593,"about_ca_system_score_gemma":0.00006792246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008999396,"about_ca_topic_score_gemma":0.000005448108,"domain_scores_codex":[0.9991715,0.0001896911,0.000181246,0.0001211396,0.0001481531,0.0001882576],"domain_scores_gemma":[0.9994103,0.00001081587,0.0002156186,0.0002277654,0.00008562612,0.00004986441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003017531,0.00009487296,0.0005785716,0.00001591678,0.00009569532,0.00000593303,0.001497356,0.000009943954,0.98945,0.001602553,0.001378063,0.004969343],"study_design_scores_gemma":[0.0003656475,0.0002482739,0.007527227,0.0000190872,0.00002107924,0.0002002077,0.0001062421,0.00001913216,0.9747622,0.005002043,0.01161805,0.0001108341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843419,0.0004933798,0.002807697,0.0001256255,0.000226308,0.0001147819,0.000008763754,0.000006532685,0.01187497],"genre_scores_gemma":[0.9978299,0.00007589848,0.001226228,0.0001214215,0.0003852937,0.000005338276,0.000004101539,0.00001384069,0.000338036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01468783,"threshold_uncertainty_score":0.2958477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.041463889186977,"score_gpt":0.2605403376875708,"score_spread":0.2190764485005938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}