{"id":"W2113476651","doi":"10.1182/blood-2012-10-457507","title":"The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Queen's University","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Von Willebrand factor; Von Willebrand disease; Allele; Molecular biology; Chemistry; Receptor; Lectin; Biology; Internal medicine; Genetics; Endocrinology; Immunology; Platelet; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303266,0.0001991382,0.0003078455,0.00008637814,0.0001913924,0.000164092,0.00008982201,0.000115222,0.0001026325],"category_scores_gemma":[0.0002963081,0.0001113205,0.00003533966,0.0001980199,0.0000605768,0.000138641,0.00005677632,0.0001879473,0.00004637636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003372381,"about_ca_system_score_gemma":0.00004043052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004806419,"about_ca_topic_score_gemma":0.0004889779,"domain_scores_codex":[0.9989085,0.00008087025,0.0002592994,0.000284021,0.0001712835,0.0002960732],"domain_scores_gemma":[0.9992327,0.0002967002,0.00008200905,0.0001920807,0.00007940709,0.0001170812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001770955,0.0009671375,0.8629126,0.00008726706,0.001391367,0.00005243165,0.00635542,0.000002670741,0.04117146,0.000161329,0.008127959,0.07699942],"study_design_scores_gemma":[0.01153344,0.0007091836,0.9614736,0.0001495449,0.0001325541,0.00005369326,0.0002393993,0.0001165668,0.004865245,0.0002965644,0.02022825,0.0002019732],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932406,0.001479881,0.00001719561,0.003759631,0.0002726845,0.001052184,0.0000340412,0.00002615713,0.0001176523],"genre_scores_gemma":[0.9978995,0.0006241848,0.00007115881,0.000318652,0.00004854826,0.00004337807,0.00001292774,0.00002334371,0.0009583231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.098561,"threshold_uncertainty_score":0.4539519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01208933617005748,"score_gpt":0.2382700665043047,"score_spread":0.2261807303342472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}