{"id":"W2113477288","doi":"10.1200/jco.2014.55.5763","title":"Pharmacokinetic and Pharmacodynamic Properties of Calaspargase Pegol <i>Escherichia coli</i> L-Asparaginase in the Treatment of Patients With Acute Lymphoblastic Leukemia: Results From Children's Oncology Group Study AALL07P4","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; University of Oklahoma Health Sciences Center; York University; Connecticut Children's Medical Center; Children's Hospitals and Clinics of Minnesota; Children's National Hospital; Seattle Children's Research Institute; University of Minnesota; Medical Center, University of Pittsburgh; University of Pittsburgh; Johns Hopkins University; Children's Hospital of Pittsburgh; Children's Hospital Colorado; Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago; Wayne State University; Cincinnati Children's Hospital Medical Center; Vanderbilt University; University of Oklahoma; Children's Hospital of Philadelphia","keywords":"Medicine; Asparaginase; Pharmacokinetics; Pharmacodynamics; PEG ratio; Pharmacology; Lymphoblastic Leukemia; Gastroenterology; Internal medicine; Leukemia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001503124,0.0006365323,0.001261902,0.0002634339,0.0002378971,0.00072136,0.0004761522,0.0007128246,0.00163346],"category_scores_gemma":[0.001417958,0.0003268122,0.0007972646,0.0003670886,0.0006707483,0.000696372,0.0002727094,0.002199919,0.0004079579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079332,"about_ca_system_score_gemma":0.0008487421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009839513,"about_ca_topic_score_gemma":0.0012776,"domain_scores_codex":[0.9993037,0.0003907002,0.0000343246,0.00008940876,0.00008523353,0.00009670971],"domain_scores_gemma":[0.9988106,0.0003024035,0.0003023309,0.0000909455,0.00004756901,0.0004461318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.766187,0.02516997,0.04709672,0.0002670361,0.001501739,0.0003065022,0.000310735,0.003910321,0.07174735,0.0001864057,0.003179452,0.08013677],"study_design_scores_gemma":[0.2296766,0.5794688,0.1596172,0.00002970753,0.001498821,0.001076448,0.0001307017,0.003264763,0.01773319,0.0002498176,0.007166448,0.00008757279],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978564,0.0007719566,0.0001703617,0.0001336671,0.0000192787,0.0001748148,0.0003902116,0.00002285025,0.0004604104],"genre_scores_gemma":[0.99773,0.0003372448,0.000355564,0.0002029176,0.00006491262,0.0001875017,0.0007069611,0.00001353659,0.000401387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00163346,"threshold_uncertainty_score":0.007949352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03771024350579944,"score_gpt":0.3682355882289499,"score_spread":0.3305253447231505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}