{"id":"W2113484361","doi":"10.1172/jci26020","title":"A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":282,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Canadian Institutes of Health Research; March of Dimes Foundation; Howard Hughes Medical Institute","keywords":"Chaperone (clinical); Protein subunit; Biology; Mitochondrion; Mitochondrial matrix; Enzyme; Genetics; Cell biology; Biochemistry; Medicine; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001748333,0.0005428895,0.0002082207,0.0003377158,0.0002393774,0.0002142531,0.0001884392,0.0003328549,0.0006077448],"category_scores_gemma":[0.0003190548,0.0001293523,0.0001368855,0.0001591944,0.0002706022,0.0001090297,0.0002668809,0.0002966071,0.0005929662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254942,"about_ca_system_score_gemma":0.0001584997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004130721,"about_ca_topic_score_gemma":0.0002506115,"domain_scores_codex":[0.9999256,0.00001507186,0.00001077255,0.00001410031,0.00001987958,0.00001460236],"domain_scores_gemma":[0.9998668,0.00001499084,0.00003317213,0.00001038022,0.00002138918,0.00005329815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004815277,0.0001033179,0.006948437,0.0001365258,0.00002743781,0.006107791,0.0000628901,0.0001628328,0.9791278,0.0002970689,0.0007537775,0.005790693],"study_design_scores_gemma":[0.0003789867,0.001337045,0.1055356,0.0001180501,0.0002146944,0.05992525,0.0002149954,0.005988038,0.8012804,0.0007236818,0.02425313,0.00002999233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961836,0.001178815,0.001274279,0.000185932,0.00006716912,0.00001964867,0.0001383742,0.0001564564,0.0007956401],"genre_scores_gemma":[0.9966909,0.0004896582,0.001256788,0.00007955964,0.00002528604,0.00001452357,0.0003915536,0.0000262271,0.001025519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006077448,"threshold_uncertainty_score":0.002033174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06430496510117388,"score_gpt":0.3770847807447986,"score_spread":0.3127798156436247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}