{"id":"W2113487676","doi":"10.1186/1423-0127-17-50","title":"Calcium-sensing receptors regulate cardiomyocyte Ca2+ signaling via the sarcoplasmic reticulum-mitochondrion interface during hypoxia/reoxygenation","year":2010,"lang":"en","type":"article","venue":"Journal of Biomedical Science","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakehead University","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China; Harbin Medical University","keywords":"Mitochondrion; Cell biology; Endoplasmic reticulum; Calcium signaling; Calcium; Apoptosis; Signal transduction; Biology; Receptor; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407902,0.000117941,0.0001337323,0.0001718144,0.0003615003,0.00007835928,0.0003316238,0.0001484776,0.00003345897],"category_scores_gemma":[0.0005071473,0.00007751401,0.0001179999,0.0004903986,0.0007269249,0.00003199554,0.0001017842,0.0003426415,0.000006237097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006603486,"about_ca_system_score_gemma":0.0001857221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009379542,"about_ca_topic_score_gemma":0.00000482152,"domain_scores_codex":[0.9982924,0.00006838508,0.000415116,0.0002361726,0.0007233944,0.0002645552],"domain_scores_gemma":[0.9988357,0.00002472002,0.0003278847,0.000207541,0.0003957716,0.0002083971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006346394,0.00001481628,0.00003277029,0.000004074471,0.00001178798,0.000003194165,0.0001066089,0.0004045527,0.9912955,0.000006110215,0.0004339295,0.00762323],"study_design_scores_gemma":[0.0004033572,0.0001750631,0.00172757,0.00003811503,0.00001585526,0.0006097372,0.0001467311,0.004681572,0.9765924,0.00006670077,0.01541808,0.0001247742],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515892,0.00007358038,0.04201224,0.001201951,0.004961952,0.00008511833,8.510381e-7,0.00000725552,0.00006789858],"genre_scores_gemma":[0.996714,0.00002360308,0.001499914,0.00007881866,0.001500158,6.370781e-7,0.00000320081,0.0000095614,0.0001701392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04512482,"threshold_uncertainty_score":0.3160929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008273444743374575,"score_gpt":0.2512910132052777,"score_spread":0.2430175684619031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}