{"id":"W2113503052","doi":"10.4049/jimmunol.165.11.6252","title":"The Quantity of TCR Signal Determines Positive Selection and Lineage Commitment of T Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"T-cell receptor; CD8; Avidity; Biology; Thymocyte; Lineage (genetic); Negative selection; T cell; Cell biology; In vivo; Molecular biology; Transgene; Major histocompatibility complex; Genetically modified mouse; Immunology; Antigen; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002514003,0.0002437954,0.0002126159,0.0004564216,0.0001204929,0.0005670614,0.0001927699,0.0002594126,0.00119549],"category_scores_gemma":[0.0003702773,0.0002335334,0.0001238548,0.0001883638,0.0002387852,0.0003835771,0.00022938,0.0005007352,0.0003853687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001489833,"about_ca_system_score_gemma":0.0001028452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008397058,"about_ca_topic_score_gemma":0.0002054121,"domain_scores_codex":[0.9996071,0.00008093249,0.00003955647,0.00008550662,0.0001171746,0.00006973431],"domain_scores_gemma":[0.9994479,0.0001737314,0.0001194579,0.00005012686,0.0000828226,0.0001259263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002869597,0.000006075988,0.0004814258,0.000006645605,9.770713e-7,0.00001387742,0.000006137499,0.00001420166,0.9989551,0.00003833944,0.000003213145,0.0004452987],"study_design_scores_gemma":[0.00001628197,0.0004357035,0.0266387,0.00001722253,0.00002718355,0.0005542396,0.00008729625,0.001198711,0.9696491,0.0002516685,0.001114994,0.000008923574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950097,0.0009091979,0.002363793,0.00003383045,0.000009273814,0.00001296705,0.0000978698,0.00002188123,0.001541589],"genre_scores_gemma":[0.996981,0.0004258022,0.001551331,0.00002148064,0.00001572163,0.00001284666,0.0001556994,0.00002068873,0.0008154315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00119549,"threshold_uncertainty_score":0.003999293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008556173681386014,"score_gpt":0.2223126677365322,"score_spread":0.2137564940551462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}