{"id":"W2113513945","doi":"10.1073/pnas.252758799","title":"RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Small interfering RNA; Replicon; RNA; RNA interference; Subgenomic mRNA; Trans-acting siRNA; DNA-directed RNA interference; Biology; RNA silencing; Virology; Molecular biology; Gene expression; Hepatitis C virus; RNA-dependent RNA polymerase; Gene silencing; Gene; Virus; Genome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005356565,0.0005767128,0.0004968439,0.0004268603,0.0002378631,0.0004326043,0.0003136114,0.0003545834,0.001194405],"category_scores_gemma":[0.000299455,0.0003630569,0.0004274973,0.0002291444,0.0003326959,0.0001703686,0.0002598233,0.0007435299,0.0009346353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004473329,"about_ca_system_score_gemma":0.0003800394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007974812,"about_ca_topic_score_gemma":0.001414924,"domain_scores_codex":[0.9995479,0.0001157229,0.00005993264,0.00006582244,0.000126067,0.00008458331],"domain_scores_gemma":[0.9998167,0.0000741949,0.00003158776,0.00003459332,0.00002238029,0.0000204756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005778711,0.00002087849,0.00002620455,0.00002826878,0.000003232195,0.00002459411,0.00001481696,0.00004173601,0.9987175,0.0001596209,0.00006065979,0.0008447699],"study_design_scores_gemma":[0.00002258117,0.000241647,0.0003066695,0.00000421932,0.000009207602,0.00006649805,0.000005057393,0.0005916119,0.9956995,0.00003327893,0.003016999,0.000002716228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9319086,0.009425169,0.04284311,0.0005027861,0.0004073968,0.0006220382,0.001519144,0.0008852425,0.01188654],"genre_scores_gemma":[0.9433201,0.006237325,0.03375304,0.0002081358,0.0001152071,0.0006570395,0.003227428,0.0002093078,0.01227248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194405,"threshold_uncertainty_score":0.003995717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540734410804137,"score_gpt":0.2663033500410798,"score_spread":0.2408960059330384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}