{"id":"W2113513945","doi":"10.1073/pnas.252758799","title":"RNA interference blocks gene expression and RNA synthesis from hepatitis C replicons propagated in human liver cells","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":304,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Small interfering RNA; Replicon; RNA; RNA interference; Subgenomic mRNA; Trans-acting siRNA; DNA-directed RNA interference; Biology; RNA silencing; Virology; Molecular biology; Gene expression; Hepatitis C virus; RNA-dependent RNA polymerase; Gene silencing; Gene; Virus; Genome; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003935633,0.0000870989,0.000112947,0.00006099532,0.00008973324,0.00001784902,0.0003687133,0.00009887708,0.00002051837],"category_scores_gemma":[0.0002826893,0.00006237531,0.00003702675,0.0001548798,0.0003776311,0.00002307894,0.0001240018,0.00008626084,4.210791e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009213453,"about_ca_system_score_gemma":0.00002199865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005403414,"about_ca_topic_score_gemma":0.000001271987,"domain_scores_codex":[0.9990882,0.00001289511,0.0002329732,0.0002966374,0.0002600494,0.0001093013],"domain_scores_gemma":[0.999597,0.00002948338,0.0002054087,0.00001482507,0.0001265754,0.00002666962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001035679,0.00003398279,0.007939975,0.000009806713,0.000007130489,1.674501e-8,0.00006502352,0.000008523998,0.9912598,0.0001893307,0.0002627163,0.0002133517],"study_design_scores_gemma":[0.00009128188,0.00006981888,0.01139358,0.0001221012,0.000005796615,0.000002443628,0.00006492154,0.00009422999,0.9861448,0.001900386,0.00003518434,0.00007541708],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977297,0.0002840546,0.000003492279,0.0000955855,0.00001174005,0.00009967473,0.0000191702,0.000002359894,0.001754198],"genre_scores_gemma":[0.9985332,0.0003023193,0.0009368984,0.00008594076,0.00002510305,0.00001218467,3.750249e-7,0.000003161821,0.0001007547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005114947,"threshold_uncertainty_score":0.2543592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02540734410804137,"score_gpt":0.2663033500410798,"score_spread":0.2408960059330384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}