{"id":"W2113563472","doi":"10.1530/jme-12-0091","title":"Posttranslational regulation of thioredoxin-interacting protein","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Endocrinology","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University of Toronto; American Diabetes Association; University of South Carolina; Eli Lilly and Company; National Institutes of Health","keywords":"TXNIP; Thioredoxin-Interacting Protein; Wortmannin; Insulin; Insulin receptor; Phosphorylation; Okadaic acid; Protein degradation; Protein kinase A; Internal medicine; Chemistry; Endocrinology; Biology; Cell biology; Phosphatase; Thioredoxin; Protein kinase B; Insulin resistance; Oxidative stress; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001467841,0.0003498938,0.0001904647,0.000179535,0.0001865033,0.0002697017,0.0001737746,0.0001994865,0.000900789],"category_scores_gemma":[0.00005963888,0.0001218409,0.0004502315,0.0001877142,0.0001743612,0.0001953513,0.0002018063,0.0004811477,0.0004378035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003303823,"about_ca_system_score_gemma":0.0001340331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000557988,"about_ca_topic_score_gemma":0.0005677241,"domain_scores_codex":[0.9998783,0.00001321433,0.000008042184,0.00004261108,0.00002673745,0.00003122129],"domain_scores_gemma":[0.9999313,0.000006591783,0.00002301305,0.000005469874,0.00001836924,0.00001520809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001167918,0.00001881137,0.0003819048,0.00006118238,0.000007991152,0.00006878855,0.00002237859,0.00002252182,0.9981319,0.00008709729,0.000065287,0.001015356],"study_design_scores_gemma":[0.00001591861,0.0001482058,0.02364802,0.00000963495,0.00002838589,0.0002937424,0.00006288274,0.000831194,0.9711016,0.00009143733,0.003760935,0.000008047095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819889,0.01052497,0.004440587,0.0002344308,0.00009652848,0.00002517354,0.0006577494,0.0001435609,0.00188814],"genre_scores_gemma":[0.9898776,0.002880635,0.002148238,0.0001060118,0.00002762914,0.00003118181,0.001152343,0.00002836836,0.00374795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000900789,"threshold_uncertainty_score":0.003013372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134792825731877,"score_gpt":0.2756248862649632,"score_spread":0.2642769580076444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}