{"id":"W2113580908","doi":"10.4306/pi.2015.12.1.125","title":"Gene Interactions and Structural Brain Change in Early-Onset Alzheimer's Disease Subjects Using the Pipeline Environment","year":2015,"lang":"en","type":"article","venue":"Psychiatry Investigation","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Nursing Research; National Institute of Mental Health; National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Synarc; National Center for Research Resources; F. Hoffmann-La Roche; National Research Foundation; Medpace; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Novartis Pharmaceuticals Corporation; Foundation for the National Institutes of Health; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; National Science Foundation","keywords":"Neuroimaging; Imaging genetics; Alzheimer's Disease Neuroimaging Initiative; Precuneus; Alzheimer's disease; Cognition; Brain size; Hippocampus; Medicine; Single-nucleotide polymorphism; Disease; Psychology; Neuroscience; Internal medicine; Magnetic resonance imaging; Biology; Genetics; Gene; Genotype; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000332496,0.0001129116,0.00009827702,0.0001192178,0.00008903853,0.00003584812,0.00004682469,0.00002747726,0.00004166228],"category_scores_gemma":[0.00007428625,0.000085149,0.00002815424,0.0001549312,0.0001424102,0.0002051002,0.00004552781,0.000173351,0.00001353666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005786134,"about_ca_system_score_gemma":0.0001322247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003312684,"about_ca_topic_score_gemma":0.00009614525,"domain_scores_codex":[0.9989741,0.000163441,0.0001801054,0.000208119,0.0002836746,0.0001905798],"domain_scores_gemma":[0.9993936,0.00003578036,0.00005952642,0.0001620691,0.00003700697,0.0003120129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001219454,0.00004096614,0.9966258,0.00001460406,0.00002357126,0.000005455654,0.0009199094,0.000009093557,0.0004082333,0.00003321407,0.0002934393,0.001503745],"study_design_scores_gemma":[0.00111309,0.0001057964,0.9826006,0.00006942693,0.0001230728,0.00003155869,0.0003567847,0.01268168,0.0004861463,0.002208155,0.0001305628,0.00009307132],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802184,0.00103119,0.0001160814,0.01764009,0.0002495567,0.0006720638,0.000014446,0.00001659546,0.00004162735],"genre_scores_gemma":[0.9965111,0.00002098144,0.0009812284,0.001969517,0.0003028599,0.00006396231,0.00009261095,0.00001312469,0.00004461658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01629275,"threshold_uncertainty_score":0.3472275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07429814549153348,"score_gpt":0.3443812917067879,"score_spread":0.2700831462152544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}