{"id":"W2113580908","doi":"10.4306/pi.2015.12.1.125","title":"Gene Interactions and Structural Brain Change in Early-Onset Alzheimer's Disease Subjects Using the Pipeline Environment","year":2015,"lang":"en","type":"article","venue":"Psychiatry Investigation","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Nursing Research; National Institute of Mental Health; National Institute on Aging; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Meso Scale Diagnostics; National Research Foundation of Korea; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Synarc; National Center for Research Resources; F. Hoffmann-La Roche; National Research Foundation; Medpace; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Novartis Pharmaceuticals Corporation; Foundation for the National Institutes of Health; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; National Science Foundation","keywords":"Neuroimaging; Imaging genetics; Alzheimer's Disease Neuroimaging Initiative; Precuneus; Alzheimer's disease; Cognition; Brain size; Hippocampus; Medicine; Single-nucleotide polymorphism; Disease; Psychology; Neuroscience; Internal medicine; Magnetic resonance imaging; Biology; Genetics; Gene; Genotype; Radiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001927058,0.0009811985,0.0006103233,0.0008680646,0.000479629,0.0009197307,0.0008020232,0.0004233003,0.006869784],"category_scores_gemma":[0.003736574,0.000419102,0.001584524,0.000693585,0.0002378638,0.0004403506,0.0009824862,0.000454044,0.001664395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003283184,"about_ca_system_score_gemma":0.0008569755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00795695,"about_ca_topic_score_gemma":0.02088471,"domain_scores_codex":[0.9992576,0.0001956972,0.00003241992,0.0003599186,0.00007619645,0.00007806844],"domain_scores_gemma":[0.9992717,0.0004347214,0.00008251474,0.00009347943,0.00006652553,0.00005111061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009690072,0.0005601798,0.6089066,0.0006996433,0.005695831,0.00120375,0.001299686,0.01759721,0.06701011,0.001486613,0.04893604,0.2369143],"study_design_scores_gemma":[0.00100386,0.001425872,0.7744958,0.00007242138,0.001978814,0.001821873,0.0002970038,0.1697438,0.0228014,0.005196077,0.02093446,0.0002286449],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8626798,0.0005993817,0.06510417,0.000550916,0.00009727325,0.0002257159,0.04189483,0.02688184,0.001966117],"genre_scores_gemma":[0.8279736,0.0002261227,0.1183731,0.0001889421,0.00004580963,0.0005804414,0.04549084,0.00255171,0.004569398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00795695,"threshold_uncertainty_score":0.02298176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07429814549153348,"score_gpt":0.3443812917067879,"score_spread":0.2700831462152544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}