{"id":"W2113597847","doi":"10.1128/jvi.06349-11","title":"Neutralizing Epitopes in the Membrane-Proximal External Region of HIV-1 gp41 Are Influenced by the Transmembrane Domain and the Plasma Membrane","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Epitope; Transmembrane protein; Human immunodeficiency virus (HIV); Membrane; Transmembrane domain; Gp41; Virology; Domain (mathematical analysis); Membrane protein; Cell biology; Biophysics; Antibody; Biochemistry; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358818,0.0002819002,0.0001490095,0.0001030058,0.0001056473,0.0002468096,0.0001307346,0.0002723327,0.0005391809],"category_scores_gemma":[0.0001572774,0.0001274199,0.0001631682,0.00009357826,0.0001994332,0.0001910786,0.0001871635,0.0004445535,0.0001694965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002678265,"about_ca_system_score_gemma":0.0001019148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005142358,"about_ca_topic_score_gemma":0.000560954,"domain_scores_codex":[0.9998342,0.0000331881,0.000009615213,0.00002472861,0.0000550681,0.00004318595],"domain_scores_gemma":[0.9999262,0.00002562699,0.00002131308,0.000007208459,0.000008218074,0.00001133788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000857241,0.000002744844,0.00008259905,0.000004117553,8.270704e-7,0.00001241802,0.000003444944,0.00002946421,0.9996862,0.00001678126,0.00000168643,0.0001510992],"study_design_scores_gemma":[0.000005330764,0.0001135021,0.00564073,0.000003585184,0.000008470142,0.0004016894,0.00002501637,0.0009329658,0.9922836,0.00003498774,0.000547578,0.000002550735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984377,0.0002850741,0.0009415494,0.00001444449,0.000002414191,0.000004067621,0.0000246489,0.000007488974,0.0002825675],"genre_scores_gemma":[0.9982998,0.0002451423,0.001011322,0.00002438007,0.000002224734,0.000006650701,0.00008742653,0.000003472853,0.0003195619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005391809,"threshold_uncertainty_score":0.00194329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01405863680011774,"score_gpt":0.2527013830613132,"score_spread":0.2386427462611954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}