{"id":"W2113602382","doi":"10.1371/journal.pone.0010513","title":"Calpain 4 Is Not Necessary for LFA-1-Mediated Function in CD4+ T Cells","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Calpain; Immunological synapse; Cell biology; T cell; CD28; Biology; Immune system; Lymphocyte function-associated antigen 1; CD8; CD3; Molecular biology; Cell adhesion molecule; T-cell receptor; Immunology; Biochemistry; Intercellular Adhesion Molecule-1","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002074697,0.00009813756,0.0001065657,0.00005734891,0.00005032218,0.00001407681,0.00006129783,0.0002296426,0.0001468784],"category_scores_gemma":[0.0001146048,0.00009658473,0.0000544947,0.00008365984,0.00003270917,0.000004371466,0.00002502376,0.0001202781,0.00003237435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008919351,"about_ca_system_score_gemma":0.00003778527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001568291,"about_ca_topic_score_gemma":0.00009005086,"domain_scores_codex":[0.9992737,0.0000282497,0.0001633702,0.0002546496,0.0001213914,0.0001586051],"domain_scores_gemma":[0.9995735,0.00002246156,0.00005456325,0.0002044456,0.0000827132,0.00006233432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002823769,0.0003603567,0.001258248,0.00004146319,0.00004620232,3.00311e-7,0.00001766508,0.000006114359,0.9941038,0.00002360641,0.003025769,0.0008340871],"study_design_scores_gemma":[0.001006232,0.000216896,0.004528676,0.00001625741,0.0000380558,5.308838e-7,0.00001622485,0.002473796,0.9700422,0.0000958378,0.02140738,0.0001578849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958141,0.00005259738,0.00225554,0.0008037661,0.0002385985,0.0004905063,0.00004410042,0.00002370949,0.0002771042],"genre_scores_gemma":[0.9940831,0.00002275552,0.000917784,0.001259,0.0004273408,0.0001109396,0.0004078959,0.00002098795,0.002750211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02406158,"threshold_uncertainty_score":0.3938611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01743343831704269,"score_gpt":0.2122546347984134,"score_spread":0.1948211964813707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}