{"id":"W2113615226","doi":"10.1371/journal.pone.0012736","title":"The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Ontario Genomics; Genome Canada; Ontario Innovation Trust; Wellcome Trust; GlaxoSmithKline","keywords":"Allosteric regulation; Pyruvate kinase; Biology; Population; Biochemistry; Protein structure; Phosphoenolpyruvate carboxykinase; Phosphofructokinase 2; Enzyme; Toxoplasma gondii; Protein kinase domain; Kinase; Glycolysis; Chemistry; Mutant; Genetics; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002357615,0.0007031956,0.0005350875,0.0001915728,0.0004703099,0.0008280349,0.0009078001,0.0007294473,0.004168265],"category_scores_gemma":[0.0005208274,0.0002842476,0.0002945738,0.0005663059,0.0002266698,0.0003973631,0.0002713946,0.001433943,0.001184267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001197295,"about_ca_system_score_gemma":0.0009538112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002353795,"about_ca_topic_score_gemma":0.002060709,"domain_scores_codex":[0.9998429,0.00001687257,0.000008360243,0.00003985909,0.00006493022,0.00002710959],"domain_scores_gemma":[0.9998024,0.00004895293,0.00003958692,0.000008317502,0.00005897933,0.00004172361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006021203,0.001343766,0.03297519,0.007698695,0.0008545732,0.006538832,0.001699287,0.02320334,0.7533852,0.01008822,0.06885844,0.0873333],"study_design_scores_gemma":[0.003494497,0.002411791,0.08911675,0.001135665,0.001428445,0.008662608,0.001981364,0.1207608,0.35304,0.008184223,0.4095151,0.0002687639],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9181787,0.02835531,0.007613732,0.003600328,0.001223336,0.0002345519,0.01114703,0.0005920177,0.02905496],"genre_scores_gemma":[0.9180939,0.0114208,0.01319803,0.0006284038,0.0001332595,0.0001609965,0.04553476,0.0001636379,0.01066624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004168265,"threshold_uncertainty_score":0.01394427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01772227637328238,"score_gpt":0.2292294153098821,"score_spread":0.2115071389365997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}