{"id":"W2113635928","doi":"10.1007/82_2012_225","title":"Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanism","year":2012,"lang":"en","type":"review","venue":"Current topics in microbiology and immunology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Hospital; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Endocytosis; Notch signaling pathway; Cell biology; Mechanism (biology); Ligand (biochemistry); T cell; Biology; Signal transduction; Hes3 signaling axis; Receptor; Cell signaling; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004619476,0.0008867622,0.001289578,0.0007993425,0.0002355002,0.001118111,0.001152509,0.001249321,0.001649748],"category_scores_gemma":[0.0002656575,0.0003232944,0.0002979491,0.001184719,0.0006228354,0.001537182,0.0007994838,0.001340116,0.001796013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009218982,"about_ca_system_score_gemma":0.0009045182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006457453,"about_ca_topic_score_gemma":0.001115097,"domain_scores_codex":[0.9998565,0.00001340959,0.00002092462,0.00003373513,0.00005778959,0.00001751952],"domain_scores_gemma":[0.9998956,0.00003150232,0.00002191712,0.000004617278,0.00003001852,0.00001636195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001961697,0.00004266473,0.0002055703,0.01048171,0.00006745249,0.0004787399,0.00005203811,0.0005455214,0.02474188,0.008662479,0.01700039,0.9375254],"study_design_scores_gemma":[0.00003962208,0.00008370302,0.001502571,0.001566579,0.0001308521,0.002115921,0.00009554218,0.0003055018,0.008261058,0.005070352,0.9807898,0.00003854389],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004829215,0.9966496,0.0007309449,0.0003028222,0.0003008481,0.000004979883,0.00002828573,0.00001677492,0.001482839],"genre_scores_gemma":[0.001536587,0.996473,0.0004632646,0.0001571814,0.0001892951,0.000006733152,0.00004466501,0.000002256074,0.001126995],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001649748,"threshold_uncertainty_score":0.006688893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02636454456192857,"score_gpt":0.2899169106945935,"score_spread":0.2635523661326649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}