{"id":"W2113637246","doi":"10.1093/glycob/cwr060","title":"N-Glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1","year":2011,"lang":"en","type":"article","venue":"Glycobiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Simon Fraser University","keywords":"Proprotein Convertases; Kexin; Zymogen; Subtilisin; Chemistry; Glycosylation; Proprotein convertase; Isozyme; Substrate (aquarium); Biochemistry; Cell biology; Enzyme; Biology; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007858261,0.0002633686,0.0002140787,0.00008087064,0.0001028033,0.0002461789,0.0001178132,0.0001705011,0.000519414],"category_scores_gemma":[0.00008194026,0.0000874231,0.000178792,0.0001109979,0.0001169172,0.0001240383,0.00009422223,0.0003133714,0.0001775011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183164,"about_ca_system_score_gemma":0.0001770808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008362269,"about_ca_topic_score_gemma":0.0009219899,"domain_scores_codex":[0.9999346,0.00001096593,0.000005429489,0.00001092392,0.00001593174,0.00002206072],"domain_scores_gemma":[0.9999585,0.000006571882,0.00001533111,0.000003070612,0.000005232002,0.00001120019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001828704,0.00002256175,0.0001862854,0.00001880971,0.00000330817,0.0000378273,0.000005735449,0.00008462226,0.998313,0.0000358884,0.00001584222,0.001093171],"study_design_scores_gemma":[0.00001619709,0.0002388343,0.004682306,0.000002486536,0.00001128335,0.0001676977,0.00001272533,0.0005495041,0.9933855,0.00002320437,0.0009076801,0.000002631103],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963355,0.001746465,0.0007445569,0.00003680346,0.000009954344,0.00001610792,0.0001103889,0.00001720471,0.0009829431],"genre_scores_gemma":[0.9965467,0.001392901,0.0008327939,0.00002979208,0.000003799505,0.00001043854,0.0001984265,0.000006154719,0.0009790836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008362269,"threshold_uncertainty_score":0.001737654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02259594219003359,"score_gpt":0.2277424000235682,"score_spread":0.2051464578335346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}