{"id":"W2113637246","doi":"10.1093/glycob/cwr060","title":"N-Glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1","year":2011,"lang":"en","type":"article","venue":"Glycobiology","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Simon Fraser University","keywords":"Proprotein Convertases; Kexin; Zymogen; Subtilisin; Chemistry; Glycosylation; Proprotein convertase; Isozyme; Substrate (aquarium); Biochemistry; Cell biology; Enzyme; Biology; LDL receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688169,0.000159758,0.0002144831,0.00005050087,0.00006919472,0.00001161798,0.00007611315,0.000232282,0.00002974152],"category_scores_gemma":[0.00006128931,0.0001418781,0.00002960214,0.0000549147,0.0002282724,0.00001170704,0.0000458498,0.0000763621,0.000001519291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004913776,"about_ca_system_score_gemma":0.00005718726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000083064,"about_ca_topic_score_gemma":0.00003584415,"domain_scores_codex":[0.9990663,0.0001005409,0.0002456745,0.0003348444,0.00004860208,0.0002040582],"domain_scores_gemma":[0.9995126,0.00001511785,0.0001859284,0.0001389875,0.00009195409,0.00005547004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005153709,0.00004723149,0.008178839,0.00008775672,0.00003355416,0.000001390976,0.0003048546,9.954442e-7,0.981176,0.000342121,0.00001531829,0.009296538],"study_design_scores_gemma":[0.0009005063,0.0006821976,0.0180114,0.00001988752,0.00002945054,0.00003194056,0.00009785707,0.00008190051,0.9786683,0.0002903587,0.001014258,0.0001719775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970082,0.001176898,0.0007768483,0.00003669769,0.00003297351,0.0004594945,0.00003118104,0.00001724681,0.0004604549],"genre_scores_gemma":[0.9989685,0.00009557763,0.0005718106,0.00008121775,0.00006168923,0.00004470713,0.0001124046,0.00001533728,0.00004877372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009832561,"threshold_uncertainty_score":0.578562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02259594219003359,"score_gpt":0.2277424000235682,"score_spread":0.2051464578335346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}