{"id":"W2113655009","doi":"10.1073/pnas.1013106107","title":"Structural basis for recognition of arginine methylated Piwi proteins by the extended Tudor domain","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; University of Toronto","funders":"Central China Normal University; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Ontario Research Foundation; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; Canadian Cancer Society Research Institute; Ontario Genomics; Wellcome Trust; Ontario Innovation Trust","keywords":"Piwi-interacting RNA; Methylation; Arginine; Nuclease; Biology; Cell biology; Biochemistry; Chemistry; DNA; Genetics; Amino acid; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008729882,0.00007569462,0.00009567072,0.00005136402,0.0001306336,0.0000092379,0.0003908777,0.0001280044,0.00001135847],"category_scores_gemma":[0.0005281626,0.00004580153,0.00007989988,0.0003024497,0.0005656508,0.00002012427,0.00005836063,0.0001036473,1.175412e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009270717,"about_ca_system_score_gemma":0.00004023487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005903351,"about_ca_topic_score_gemma":6.668476e-7,"domain_scores_codex":[0.9990297,0.000006950732,0.0002532544,0.0001902261,0.0004179909,0.0001018744],"domain_scores_gemma":[0.9990885,0.00003844969,0.0004445186,0.00001311229,0.000397845,0.00001757679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005399306,0.0000127966,0.0001340927,0.00002170119,0.00002254317,1.664624e-10,0.00004208993,0.00002536214,0.9961199,0.0009094324,0.0005745005,0.002083558],"study_design_scores_gemma":[0.0002424993,0.0001004555,0.008412558,0.00002018897,0.00001572886,0.000003941159,0.00006216996,0.0004486109,0.9684063,0.02187801,0.000351318,0.00005821655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967997,0.0001142346,0.0000110559,0.002172896,0.00003472267,0.0004463309,0.00009202099,0.000003108984,0.0003259399],"genre_scores_gemma":[0.9960825,0.00001092832,0.003619257,0.00005263384,0.0001063772,0.00003734,0.000004424281,0.000004607376,0.00008191693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02771363,"threshold_uncertainty_score":0.2084164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02195971143590905,"score_gpt":0.2935379856925142,"score_spread":0.2715782742566051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}