{"id":"W2113690180","doi":"10.1128/aac.02352-14","title":"Discovery of Novel Cell Wall-Active Compounds Using P <sub> <i>ywaC</i> </sub> , a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Bacillus subtilis; Cell wall; Bacterial cell structure; Biology; Cell; Bacteria; Drug discovery; Cell growth; Microbiology; Lipid II; Gram-positive bacteria; Antimicrobial; Biochemistry; Peptidoglycan; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002520245,0.0007555038,0.0006687301,0.0004543661,0.0002629524,0.0004438254,0.0003391231,0.0004928732,0.0005259564],"category_scores_gemma":[0.0003224073,0.0002474687,0.0004168838,0.0004323956,0.0003646532,0.0003070233,0.0003121569,0.0005155678,0.0002786729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003740935,"about_ca_system_score_gemma":0.0004127702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010178,"about_ca_topic_score_gemma":0.002368514,"domain_scores_codex":[0.9998059,0.0000390978,0.00001525836,0.00003989237,0.00007330125,0.00002658974],"domain_scores_gemma":[0.9997918,0.00005734567,0.00005487677,0.00001821391,0.00003392593,0.00004389605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000878664,0.0001267564,0.0002075103,0.00007083261,0.00001121121,0.00007065733,0.0000181917,0.0003876868,0.9940422,0.00006071585,0.00003779573,0.004878575],"study_design_scores_gemma":[0.00004396482,0.002178252,0.001189531,0.000006030109,0.00002949697,0.0001404578,0.00001899668,0.0004438389,0.9947136,0.00002631968,0.001200119,0.000009271594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775544,0.004061547,0.0137889,0.0002229169,0.00004682865,0.0006891232,0.0008210717,0.0003525986,0.002462747],"genre_scores_gemma":[0.9637618,0.005333489,0.02611747,0.0001497257,0.00001979751,0.0002772317,0.001172578,0.00005795773,0.003109923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010178,"threshold_uncertainty_score":0.002714276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009534395451235045,"score_gpt":0.2130361158877391,"score_spread":0.2035017204365041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}