{"id":"W2113690180","doi":"10.1128/aac.02352-14","title":"Discovery of Novel Cell Wall-Active Compounds Using P <sub> <i>ywaC</i> </sub> , a Sensitive Reporter of Cell Wall Stress, in the Model Gram-Positive Bacterium Bacillus subtilis","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Bacillus subtilis; Cell wall; Bacterial cell structure; Biology; Cell; Bacteria; Drug discovery; Cell growth; Microbiology; Lipid II; Gram-positive bacteria; Antimicrobial; Biochemistry; Peptidoglycan; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535971,0.0002721542,0.0003709305,0.00005720976,0.00005889397,0.00003509092,0.0002029716,0.0003026183,0.000001150196],"category_scores_gemma":[0.000004684442,0.0002167167,0.0001345301,0.0001041713,0.0002809053,0.00001390874,0.0001088876,0.0001255188,1.736354e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000135303,"about_ca_system_score_gemma":0.00005506599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001717619,"about_ca_topic_score_gemma":0.00007443637,"domain_scores_codex":[0.9986836,0.00006740865,0.0004084976,0.0004405506,0.000110265,0.0002896377],"domain_scores_gemma":[0.9991425,0.00001501666,0.0003487083,0.0003483184,0.0001125657,0.00003284546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003642572,0.000538399,0.0006251321,0.00004817552,0.00005482526,0.000002550285,0.0004470611,0.00008941536,0.9972974,0.000009432919,0.0001835542,0.0003397719],"study_design_scores_gemma":[0.001565148,0.0003040041,0.003011876,0.00004429868,0.0000377073,0.00001878771,0.0000923807,0.001663146,0.9926601,0.00001210403,0.0003443838,0.0002460657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973742,0.00001580804,0.001519258,0.0002802166,0.00006903336,0.0002947529,0.0002727644,0.000004186848,0.0001698055],"genre_scores_gemma":[0.9967415,0.0006199128,0.0006758154,0.00164683,0.00005994178,0.000002944324,0.000191355,0.00003179792,0.00002988324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004637327,"threshold_uncertainty_score":0.8837448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009534395451235045,"score_gpt":0.2130361158877391,"score_spread":0.2035017204365041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}