{"id":"W2113709410","doi":"10.4155/tde.14.37","title":"Enhancing siRNA Delivery By Employing Lipid Nanoparticles","year":2014,"lang":"en","type":"review","venue":"Therapeutic Delivery","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Nucleic acid; Gene silencing; Oligonucleotide; Intracellular; Cytoplasm; Nanotechnology; Gene delivery; Small interfering RNA; Transfection; microRNA; Chemistry; Biophysics; Computational biology; Cell biology; Biology; Materials science; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004151135,0.0007782693,0.001343082,0.0001362771,0.0001899213,0.0001174556,0.0008160407,0.0006637134,0.0001010726],"category_scores_gemma":[0.0000305063,0.0006863008,0.0007740699,0.0001765139,0.0001370043,0.00001311195,0.000291997,0.0003644275,0.0005819168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006318837,"about_ca_system_score_gemma":0.0002664825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003658269,"about_ca_topic_score_gemma":0.00002247302,"domain_scores_codex":[0.9967866,0.0003679132,0.00087621,0.0009571175,0.0002886358,0.0007235305],"domain_scores_gemma":[0.9982119,0.00009848111,0.0004143044,0.0009511786,0.0001412395,0.0001829556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004200929,0.0000780424,0.00000850027,0.001634308,0.0006322397,0.000006744388,0.00003122676,0.000002104358,0.072476,0.000008010178,0.004858769,0.920222],"study_design_scores_gemma":[0.0002380013,0.0003616615,0.000001298004,0.002131121,0.0006402137,0.00005091948,0.00003550555,0.000006776218,0.01817882,0.00001409533,0.9775149,0.0008267217],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01563139,0.9824761,0.0003914497,0.00001282622,0.0006001279,0.0004324395,0.00006430185,0.00006471528,0.0003266954],"genre_scores_gemma":[0.005868009,0.9899824,0.0001099842,0.0007548792,0.0008570962,0.0001002337,0.0004424918,0.0001571493,0.001727782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9726561,"threshold_uncertainty_score":0.9995588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03097109075043546,"score_gpt":0.2998366878893362,"score_spread":0.2688655971389007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}