{"id":"W2113709410","doi":"10.4155/tde.14.37","title":"Enhancing siRNA Delivery By Employing Lipid Nanoparticles","year":2014,"lang":"en","type":"review","venue":"Therapeutic Delivery","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"","keywords":"Nucleic acid; Gene silencing; Oligonucleotide; Intracellular; Cytoplasm; Nanotechnology; Gene delivery; Small interfering RNA; Transfection; microRNA; Chemistry; Biophysics; Computational biology; Cell biology; Biology; Materials science; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000272255,0.0007129496,0.000569448,0.001287484,0.0001390938,0.0004907444,0.0003558867,0.0006867036,0.0006304444],"category_scores_gemma":[0.0001524495,0.0002119118,0.0002891749,0.0006124096,0.0002758771,0.0005492315,0.0004745855,0.0007126929,0.00080294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000490096,"about_ca_system_score_gemma":0.0003956665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007062746,"about_ca_topic_score_gemma":0.0007516641,"domain_scores_codex":[0.9998952,0.00001798131,0.000008987373,0.00002186944,0.00004037076,0.00001560535],"domain_scores_gemma":[0.9999613,0.0000131292,0.000007987266,0.000001392044,0.00001235947,0.000003865319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001009774,0.000141131,0.0002366348,0.01190609,0.00009551249,0.0007884717,0.0001660378,0.001252639,0.3673966,0.009353396,0.005785948,0.6027766],"study_design_scores_gemma":[0.00003517676,0.0004410801,0.0008527779,0.001006273,0.0001544859,0.003362623,0.00006794855,0.001129144,0.2455865,0.002064648,0.7452455,0.0000538004],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006334239,0.9816461,0.005934721,0.0003396629,0.0001679956,0.00004051337,0.00003188336,0.0000744664,0.005430341],"genre_scores_gemma":[0.03024891,0.9591094,0.005287827,0.0003359389,0.0001161774,0.0000659242,0.00007765363,0.00001248289,0.00474566],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001287484,"threshold_uncertainty_score":0.003555954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03097109075043546,"score_gpt":0.2998366878893362,"score_spread":0.2688655971389007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}