{"id":"W2113735219","doi":"10.1186/s12977-014-0117-5","title":"How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest","year":2014,"lang":"en","type":"review","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nautical Research Society","funders":"Ministère de l'Enseignement Supérieur et de la Recherche; Agence Nationale de la Recherche; Fondation de France; Sidaction; Fondation pour la Recherche Médicale; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Endonuclease; Cell cycle checkpoint; Human immunodeficiency virus (HIV); Function (biology); Mechanism (biology); Innate immune system; Biology; Viral life cycle; Cell biology; Cell cycle; Computational biology; Cell; Immune system; Virology; Virus; Viral replication; Immunology; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003475227,0.0005757714,0.002371714,0.0001733814,0.0001856477,0.00002273246,0.0009088782,0.001293215,0.000400382],"category_scores_gemma":[0.0002308732,0.0003339164,0.0006758097,0.0002486554,0.0009391337,0.00005713123,0.0002986516,0.001195622,0.007501678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009455548,"about_ca_system_score_gemma":0.0002964322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007509113,"about_ca_topic_score_gemma":0.00002739484,"domain_scores_codex":[0.9957976,0.00189536,0.0006537599,0.000647145,0.00008890298,0.0009171713],"domain_scores_gemma":[0.99652,0.001549363,0.000653844,0.001157795,0.0000671834,0.00005179638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005011733,0.001889191,0.0006099179,0.02890951,0.008294201,0.0004121299,0.0009191723,0.000003782459,0.002072389,0.001698846,0.206975,0.7477146],"study_design_scores_gemma":[0.0008776947,0.0006276412,0.0000265695,0.0004204618,0.0005600956,0.0001185205,0.00002739645,3.104035e-7,0.00007199492,0.00003435679,0.996989,0.0002460036],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002161212,0.9928232,0.00007292975,0.0004726998,0.0009023717,0.0009303463,0.0008209739,0.00005694305,0.003704454],"genre_scores_gemma":[0.004318962,0.9816386,0.00002336172,0.0001070038,0.0001510378,0.0001967634,0.002971904,0.00006757507,0.01052484],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7900139,"threshold_uncertainty_score":0.9999113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02346708623994153,"score_gpt":0.2818107093409744,"score_spread":0.2583436231010328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}