{"id":"W2113768469","doi":"10.4049/jimmunol.1200150","title":"PTPN22 Alters the Development of Regulatory T Cells in the Thymus","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute of Allergy and Infectious Diseases; Thailand Science Research and Innovation; Wellcome Trust","keywords":"PTPN22; Protein tyrosine phosphatase; Experimental autoimmune encephalomyelitis; T-cell receptor; Immunology; Thymectomy; Biology; Phosphatase; Proto-oncogene tyrosine-protein kinase Src; Kinase; Cell biology; T cell; Multiple sclerosis; Myasthenia gravis; Phosphorylation; Genetics; Gene; Genotype; Immune system; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001522291,0.00007232662,0.0001132767,0.00002649333,0.00006738651,0.000004087572,0.0004760163,0.00006800056,0.000009271453],"category_scores_gemma":[0.00004062928,0.00003223139,0.0000674136,0.00006610609,0.0001403105,0.000004000032,0.00006911691,0.000167555,0.000003089222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001211205,"about_ca_system_score_gemma":0.00007425709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004973608,"about_ca_topic_score_gemma":0.000009344384,"domain_scores_codex":[0.9990738,0.000284139,0.0002989452,0.0000366231,0.0001013734,0.0002051361],"domain_scores_gemma":[0.9993746,0.00006591417,0.0002978987,0.0002032618,0.00004558538,0.00001279613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407234,0.0001852201,0.002358772,0.000005158915,0.0003414218,4.625617e-7,0.005642517,0.00008262698,0.9753922,0.0001241921,0.002116355,0.01361032],"study_design_scores_gemma":[0.001516866,0.000503,0.1293697,0.0000395674,0.0001085032,0.00006704249,0.01801873,0.000003564245,0.7327435,0.0002638279,0.1171584,0.000207257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896031,0.008894281,0.00003827292,0.0006409741,0.0002463071,0.00006098028,9.467733e-7,6.166877e-7,0.0005145012],"genre_scores_gemma":[0.9989012,0.0005190709,0.00007297411,0.0003720998,0.00006537758,0.000001547933,0.000001293377,0.000005986714,0.00006041271],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2426487,"threshold_uncertainty_score":0.1314358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007044681785002214,"score_gpt":0.2169692351678579,"score_spread":0.2099245533828557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}