{"id":"W2113768469","doi":"10.4049/jimmunol.1200150","title":"PTPN22 Alters the Development of Regulatory T Cells in the Thymus","year":2012,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juvenile Diabetes Research Foundation","funders":"National Institute of Allergy and Infectious Diseases; Thailand Science Research and Innovation; Wellcome Trust","keywords":"PTPN22; Protein tyrosine phosphatase; Experimental autoimmune encephalomyelitis; T-cell receptor; Immunology; Thymectomy; Biology; Phosphatase; Proto-oncogene tyrosine-protein kinase Src; Kinase; Cell biology; T cell; Multiple sclerosis; Myasthenia gravis; Phosphorylation; Genetics; Gene; Genotype; Immune system; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001954388,0.0003374944,0.0002884901,0.0003373468,0.0001070565,0.0003562375,0.0001624295,0.0003670709,0.001642594],"category_scores_gemma":[0.0003063377,0.0001715452,0.00017859,0.0001248761,0.0002467593,0.0002437561,0.0001827145,0.0006902789,0.0002399054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001736146,"about_ca_system_score_gemma":0.0001585363,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003077571,"about_ca_topic_score_gemma":0.0004072492,"domain_scores_codex":[0.9997495,0.00006706145,0.00002137803,0.00005547894,0.00004182769,0.00006476608],"domain_scores_gemma":[0.9996356,0.00004920225,0.00008293349,0.00003440063,0.00002556182,0.0001722292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003606781,0.00004565401,0.0005228787,0.00001567107,0.000005783425,0.0001081752,0.00001213357,0.00003590697,0.9976357,0.00005009686,0.00001378864,0.001193398],"study_design_scores_gemma":[0.0001153321,0.001855409,0.04647065,0.00002085416,0.0001041051,0.001814045,0.0001136166,0.001455784,0.9457186,0.0002439066,0.002073001,0.00001479891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982094,0.0006405477,0.0004301213,0.00003845394,0.0000185165,0.000005639949,0.00008470172,0.00002788471,0.0005447623],"genre_scores_gemma":[0.9983549,0.0003132805,0.0002889397,0.00002810858,0.000008829926,0.000007857589,0.00009355965,0.00001327463,0.0008912348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642594,"threshold_uncertainty_score":0.005495012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007044681785002214,"score_gpt":0.2169692351678579,"score_spread":0.2099245533828557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}