{"id":"W2113780394","doi":"10.1371/journal.pmed.1001196","title":"No Treatment versus 24 or 60 Weeks of Antiretroviral Treatment during Primary HIV Infection: The Randomized Primo-SHM Trial","year":2012,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Stichting Sanquin Bloedvoorziening; Universiteit Maastricht; Universitair Medisch Centrum Utrecht; Erasmus Medisch Centrum; Leids Universitair Medisch Centrum; Maastricht Universitair Medisch Centrum","keywords":"Cart; Medicine; Randomized controlled trial; Randomization; Clinical endpoint; Viral load; Intention-to-treat analysis; Internal medicine; Antiretroviral therapy; Surgery; Human immunodeficiency virus (HIV); Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004796985,0.000521786,0.001789665,0.0002355441,0.000193545,0.000009183804,0.00009071242,0.0001339709,0.0009806176],"category_scores_gemma":[0.0004541001,0.0002299299,0.0003788382,0.0002718091,0.0003669234,0.0001333269,0.00004477318,0.0001535212,0.0002067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009685862,"about_ca_system_score_gemma":0.0003063009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001537636,"about_ca_topic_score_gemma":0.00001973506,"domain_scores_codex":[0.9972162,0.0002592661,0.0008894138,0.0003594225,0.0007064528,0.0005692653],"domain_scores_gemma":[0.9977638,0.0008824286,0.0003391239,0.0005785913,0.0001215423,0.0003145284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.958437,0.005191321,0.01651451,0.0002405962,0.005388449,0.0001854849,0.005174494,7.808636e-7,0.001733235,0.00006377803,0.001636563,0.005433766],"study_design_scores_gemma":[0.9521869,0.008563418,0.003864742,0.0003895768,0.005102901,0.00005307991,0.0001843783,0.00003250758,0.009691924,0.000003810859,0.01967784,0.0002489356],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690048,0.001854556,0.00001092566,0.004049207,0.002118225,0.004512212,0.00001154448,0.0001510238,0.01828754],"genre_scores_gemma":[0.9014022,0.003952375,0.0004958541,0.0001121399,0.003868566,0.0009493213,0.0002571497,0.0000720238,0.08889034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0706028,"threshold_uncertainty_score":0.9999326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04625949345079913,"score_gpt":0.2914848146627578,"score_spread":0.2452253212119587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}