{"id":"W2113833115","doi":"10.1038/nature04835","title":"ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":927,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"H3K4me3; Histone H3; Histone; Effector; Biology; Cell biology; Histone methylation; Chromatin; Histone deacetylase 2; Chromatin immunoprecipitation; Histone code; Promoter; Chemistry; Genetics; Histone deacetylase; DNA methylation; Gene; Gene expression; Nucleosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002006597,0.0003443924,0.0002652781,0.0002024081,0.0003868218,0.0006597554,0.0007866308,0.0004008414,0.004812339],"category_scores_gemma":[0.000218618,0.0003146923,0.0002856059,0.0001729729,0.000415177,0.0003614701,0.0005990801,0.000836531,0.001350741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006057922,"about_ca_system_score_gemma":0.0003568165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695837,"about_ca_topic_score_gemma":0.002481259,"domain_scores_codex":[0.9998885,0.000008749551,0.000004489516,0.00003343921,0.00002678867,0.00003785995],"domain_scores_gemma":[0.9998857,0.00001416612,0.00002086524,0.00002208522,0.00001483191,0.00004237586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004606585,0.00004119023,0.0006750196,0.00005298532,0.0000132867,0.0001647961,0.00001955022,0.0003145844,0.9913966,0.00133581,0.0008530594,0.004672542],"study_design_scores_gemma":[0.00001647855,0.00004450091,0.00533549,0.000002342721,0.00001056066,0.0002064815,0.00002379351,0.001708629,0.986912,0.0004583593,0.005274715,0.000006720126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520081,0.003048002,0.02342577,0.0009150496,0.0002851806,0.00003981889,0.001314132,0.0009970837,0.0179669],"genre_scores_gemma":[0.9817061,0.0005331436,0.002848305,0.0001671829,0.00003761381,0.00001552014,0.001167012,0.00006864551,0.01345651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004812339,"threshold_uncertainty_score":0.01609886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006637168087479237,"score_gpt":0.2857316571902206,"score_spread":0.2790944891027414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}