{"id":"W2113835324","doi":"10.1016/j.bmc.2005.02.011","title":"Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Moiety; Peptidomimetic; Protease; Stereochemistry; Tetrahedral carbonyl addition compound; Hydrolysis; Aqueous solution; Ether; HIV-1 protease; Combinatorial chemistry; Oxyanion; Peptide; Enzyme; Organic chemistry; Nucleophile; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003610238,0.0003707897,0.0003481987,0.0001406817,0.0001720575,0.0002050575,0.0003620799,0.0003268951,0.000586556],"category_scores_gemma":[0.0003136066,0.0001576784,0.0001771935,0.0001471253,0.0001587247,0.0003490195,0.0001250604,0.0004845642,0.0001942884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003627106,"about_ca_system_score_gemma":0.000162686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003915424,"about_ca_topic_score_gemma":0.0004182403,"domain_scores_codex":[0.9998956,0.00001783852,0.00001217059,0.00001882198,0.00002637434,0.00002928807],"domain_scores_gemma":[0.9999198,0.00002051846,0.0000215199,0.000007794391,0.00001437866,0.00001594386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005163985,0.0001017561,0.00009212029,0.00007591779,0.00001176287,0.0001820553,0.00004620456,0.0003952106,0.9894534,0.000252016,0.000172953,0.00870015],"study_design_scores_gemma":[0.00009230381,0.001035127,0.0004264907,0.000004336508,0.00002147752,0.0005906998,0.000007050969,0.0007610854,0.9939238,0.00005096407,0.003079393,0.000007215479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9671112,0.01063789,0.01876147,0.0002289152,0.00008361749,0.0002239381,0.0005615216,0.000142942,0.002248621],"genre_scores_gemma":[0.9805434,0.005397392,0.0103244,0.0001115384,0.00003265775,0.0001328682,0.000586073,0.00002773763,0.002843987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000586556,"threshold_uncertainty_score":0.002631664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000949939648087,"score_gpt":0.2546134931688378,"score_spread":0.2346039937723569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}