{"id":"W2113835324","doi":"10.1016/j.bmc.2005.02.011","title":"Novel fluoropeptidomimetics: synthesis, stability studies and protease inhibition","year":2005,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Moiety; Peptidomimetic; Protease; Stereochemistry; Tetrahedral carbonyl addition compound; Hydrolysis; Aqueous solution; Ether; HIV-1 protease; Combinatorial chemistry; Oxyanion; Peptide; Enzyme; Organic chemistry; Nucleophile; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003413274,0.0002354302,0.0002995675,0.00001468069,0.00009482286,0.00001786982,0.0001175815,0.0001735345,0.0002381152],"category_scores_gemma":[0.001061692,0.0001941588,0.00009802307,0.00009564305,0.0003008064,0.000005973357,0.0001529343,0.0001284399,0.000009456706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005716157,"about_ca_system_score_gemma":0.00005846678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001033492,"about_ca_topic_score_gemma":0.000006123684,"domain_scores_codex":[0.9986621,0.00002461045,0.0003232994,0.0005144684,0.0002197623,0.0002557895],"domain_scores_gemma":[0.9991941,0.00005005354,0.0001093622,0.0003441713,0.0001149694,0.000187356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004992957,0.0001039791,0.0003105745,0.0001515866,0.0001137186,0.000001654666,0.00003827078,2.513247e-7,0.9933171,0.000002026681,0.0005442052,0.005366727],"study_design_scores_gemma":[0.0004139526,0.00002930074,0.000190834,0.00009240738,0.0001401911,0.00004053279,0.0004214259,0.00001787298,0.9931239,0.00001516029,0.005285911,0.0002284815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915938,0.006333985,0.000250693,0.001284761,0.00001879583,0.0001204937,0.00002275375,0.00002440663,0.0003503542],"genre_scores_gemma":[0.9967272,0.0007114992,0.001138859,0.0002076108,0.000907869,0.00003724048,0.00003218665,0.00002269976,0.0002148566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005622486,"threshold_uncertainty_score":0.7917567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02000949939648087,"score_gpt":0.2546134931688378,"score_spread":0.2346039937723569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}