{"id":"W2113865865","doi":"10.1186/s13058-014-0474-y","title":"Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; McMaster University Medical Centre; Canada Research Chairs; University Health Network; University of New Brunswick; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; School of Medicine; U.S. Department of Defense; Cancer Research UK; Universität Ulm; National Health and Medical Research Council; Universiti Malaya; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Kommunfullmäktige, Stockholms Stad; Ministero della Salute; Academy of Finland; Robert Bosch Stiftung; Cancer Research Institute; Agency for Science, Technology and Research; National Breast Cancer Foundation; Cancer Center, University of Kansas; Cancerfonden; Fundación Mutua Madrileña; National Cancer Institute; Cancer Institute NSW; Breast Cancer Campaign; National Institute for Health and Care Research; KWF Kankerbestrijding; Peter MacCallum Cancer Centre; Herlev Hospital; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; University of Westminster; Deutsches Krebsforschungszentrum; Kansas Bioscience Authority; Sundhed og Sygdom, Det Frie Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Itä-Suomen Yliopisto; Helsingin ja Uudenmaan Sairaanhoitopiiri; Fox Chase Cancer Center; Eberhard Karls Universität Tübingen; Memorial Sloan-Kettering Cancer Center; Susan G. Komen for the Cure; Rheinische Friedrich-Wilhelms-Universität Bonn; Beth Israel Deaconess Medical Center; Royal Marsden NHS Foundation Trust; Huntsman Cancer Institute; Mayo Clinic; Breast Cancer Research Foundation","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Internal medicine; Scale (ratio); Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007895226,0.000150831,0.0003415493,0.0001401652,0.0001382082,0.00002875101,0.0002080419,0.0001607314,0.0001915929],"category_scores_gemma":[0.0001394815,0.0001170268,0.0000762724,0.0004860612,0.0006789021,0.000008927342,0.0002163571,0.0001945626,5.77791e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001137407,"about_ca_system_score_gemma":0.0003646095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002537561,"about_ca_topic_score_gemma":0.002578913,"domain_scores_codex":[0.9980024,0.0003737222,0.000370821,0.0004957341,0.000405135,0.0003522123],"domain_scores_gemma":[0.9984921,0.0001527019,0.0001971962,0.0004387404,0.0006002102,0.0001190687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006718193,0.0001004604,0.8263734,0.00005645359,0.0006195633,0.0000012069,0.0009459209,0.00009919013,0.1520012,0.00006968553,0.0008513005,0.01820978],"study_design_scores_gemma":[0.0006630931,0.00008176474,0.9903064,0.00003717816,0.0003101951,0.000009854222,0.0003605326,0.001212298,0.003458717,0.00003526016,0.003400787,0.0001239713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898087,0.001862751,0.000372089,0.00116365,0.00008722391,0.0002154158,0.006417251,0.000006672517,0.00006629535],"genre_scores_gemma":[0.9971745,0.001804992,0.0001519009,0.0001182191,0.0002245043,0.0001216444,0.0002904666,0.0000200803,0.00009367281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1639329,"threshold_uncertainty_score":0.4772214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855494741682273,"score_gpt":0.3246105402506982,"score_spread":0.3060555928338755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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