{"id":"W2113865865","doi":"10.1186/s13058-014-0474-y","title":"Refined histopathological predictors of BRCA1 and BRCA2mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Hospital; McMaster University Medical Centre; Canada Research Chairs; University Health Network; University of New Brunswick; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Universitätsklinikum Hamburg-Eppendorf; Instituto de Salud Carlos III; Cancer Council Victoria; Medical Research Council; Canadian Institutes of Health Research; School of Medicine; U.S. Department of Defense; Cancer Research UK; Universität Ulm; National Health and Medical Research Council; Universiti Malaya; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Deutsche Gesetzliche Unfallversicherung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Kommunfullmäktige, Stockholms Stad; Ministero della Salute; Academy of Finland; Robert Bosch Stiftung; Cancer Research Institute; Agency for Science, Technology and Research; National Breast Cancer Foundation; Cancer Center, University of Kansas; Cancerfonden; Fundación Mutua Madrileña; National Cancer Institute; Cancer Institute NSW; Breast Cancer Campaign; National Institute for Health and Care Research; KWF Kankerbestrijding; Peter MacCallum Cancer Centre; Herlev Hospital; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; University of Westminster; Deutsches Krebsforschungszentrum; Kansas Bioscience Authority; Sundhed og Sygdom, Det Frie Forskningsråd; Associazione Italiana per la Ricerca sul Cancro; Itä-Suomen Yliopisto; Helsingin ja Uudenmaan Sairaanhoitopiiri; Fox Chase Cancer Center; Eberhard Karls Universität Tübingen; Memorial Sloan-Kettering Cancer Center; Susan G. Komen for the Cure; Rheinische Friedrich-Wilhelms-Universität Bonn; Beth Israel Deaconess Medical Center; Royal Marsden NHS Foundation Trust; Huntsman Cancer Institute; Mayo Clinic; Breast Cancer Research Foundation","keywords":"Surgical oncology; Breast cancer; Medicine; Oncology; Internal medicine; Scale (ratio); Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0090274,0.0005276129,0.001002523,0.003965328,0.0008727438,0.001666555,0.001360669,0.0006825796,0.00178025],"category_scores_gemma":[0.0213111,0.000438779,0.001198334,0.006059796,0.0007705468,0.0007077711,0.002865222,0.0009279281,0.0005310255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008626814,"about_ca_system_score_gemma":0.001361069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01760866,"about_ca_topic_score_gemma":0.02326663,"domain_scores_codex":[0.9950937,0.001928993,0.0003716098,0.001135897,0.001057995,0.0004117199],"domain_scores_gemma":[0.9782954,0.006442353,0.006596702,0.004584027,0.00233007,0.001751416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002060784,0.00002152165,0.9953621,0.00003941125,0.0004280159,0.00004300632,0.0001048875,0.0002198785,0.0001810223,0.0000448312,0.00111597,0.002233193],"study_design_scores_gemma":[0.0000300713,0.00002602298,0.9974745,0.00002303827,0.0002015607,0.000156473,0.0001829541,0.0007527224,0.00005931301,0.000055498,0.001028875,0.000008826296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863842,0.0008639089,0.0006195528,0.0002007554,0.00001365988,0.00005347413,0.01138754,0.00003062878,0.0004462808],"genre_scores_gemma":[0.9669516,0.000269153,0.00107649,0.00009487301,0.00003194597,0.0001283965,0.03121074,0.00003104565,0.0002057919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01760866,"threshold_uncertainty_score":0.04774207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01855494741682273,"score_gpt":0.3246105402506982,"score_spread":0.3060555928338755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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