{"id":"W2113908393","doi":"10.18433/j3ns3x","title":"Interactions between Phytochemical Components of Sutherlandia Frutescens and the Antiretroviral, Atazanavir In Vitro: Implications for Absorption and Metabolism","year":2012,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; Rhodes University; National Research Foundation; Atlantic Philanthropies","keywords":"Atazanavir; Phytochemical; Glycoside; Chemistry; Microsome; Biochemistry; Traditional medicine; Chromatography; Biology; In vitro; Organic chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000860497,0.0002937263,0.0002101907,0.0002041255,0.0001278334,0.0001423401,0.0001007462,0.0001800601,0.0009853612],"category_scores_gemma":[0.00008746571,0.00007625976,0.0002426697,0.0001682888,0.0001268744,0.0001456124,0.0001004437,0.0002849338,0.0001693378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351999,"about_ca_system_score_gemma":0.0001674355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177877,"about_ca_topic_score_gemma":0.002089011,"domain_scores_codex":[0.9999572,0.00001218558,0.000003768842,0.00000742026,0.00001059752,0.000008800163],"domain_scores_gemma":[0.9999175,0.00003044299,0.00002081308,0.000008260592,0.00001194987,0.00001096219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002149663,0.00008356141,0.0006303244,0.00006857716,0.00001373808,0.00004508793,0.00001700592,0.00007191329,0.9968219,0.00002263761,0.00001626081,0.001994094],"study_design_scores_gemma":[0.00004407436,0.003002983,0.04510507,0.00002433553,0.00009444427,0.0004155686,0.00008982667,0.0009394027,0.9482831,0.0000570814,0.001933653,0.00001054678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953403,0.002887524,0.0005030771,0.0000527476,0.0000105267,0.00001787091,0.0002612891,0.00001855693,0.0009080055],"genre_scores_gemma":[0.996035,0.001287539,0.001014875,0.00005504489,0.00001142619,0.00001321874,0.0005091544,0.000004861668,0.001068911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177877,"threshold_uncertainty_score":0.003296316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09578712185318233,"score_gpt":0.4174371925466226,"score_spread":0.3216500706934403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}