{"id":"W2113914428","doi":"10.1016/j.exphem.2010.02.002","title":"Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells","year":2010,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Haematopoiesis; Progenitor cell; CD34; Cell biology; Biology; Bone marrow; Stem cell; Myeloid; Complement system; Chemistry; Molecular biology; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965153,0.0002565061,0.0001194192,0.0002130754,0.0001811816,0.0003514815,0.0002756339,0.0003685631,0.002579961],"category_scores_gemma":[0.000153867,0.0001106619,0.0002220943,0.00009005409,0.0002566355,0.0001655285,0.0001878494,0.0007019506,0.0002788444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004409075,"about_ca_system_score_gemma":0.0004912962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001208178,"about_ca_topic_score_gemma":0.001713734,"domain_scores_codex":[0.9998353,0.0000296094,0.00001097783,0.00001639317,0.00004256461,0.00006522533],"domain_scores_gemma":[0.9998916,0.00002848756,0.00002684015,0.00001542653,0.000006217328,0.00003139548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003627254,0.00005347226,0.0001954908,0.00001682634,0.000009263568,0.00006675687,0.000009897836,0.0001363088,0.9965509,0.0008371048,0.0001246568,0.001636572],"study_design_scores_gemma":[0.00004136283,0.0002521179,0.001946279,0.000003683743,0.00001210646,0.0001896133,0.00001762896,0.0007431621,0.9955822,0.0001219605,0.001086819,0.000003089558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995019,0.000802838,0.00190734,0.000230826,0.00003751666,0.00002392257,0.0002750636,0.0000365691,0.00166703],"genre_scores_gemma":[0.9968092,0.0002239719,0.001246792,0.00007797845,0.000006586768,0.00001178281,0.0002523687,0.00001058691,0.001360801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002579961,"threshold_uncertainty_score":0.008630812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04097734757901361,"score_gpt":0.3075058005507419,"score_spread":0.2665284529717283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}