{"id":"W2113929040","doi":"10.1242/jcs.070938","title":"Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth","year":2010,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"LRP1; Biology; Cell biology; Fibroblast; Cancer cell; Paracrine signalling; Cancer research; Cancer; LDL receptor; Cell culture; Receptor; Lipoprotein; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001111876,0.00008882139,0.0001155351,0.00003788963,0.00009378306,0.00002677836,0.0005148797,0.0000483417,0.000006316285],"category_scores_gemma":[0.0000771566,0.0000414483,0.00005707128,0.0001267666,0.0005101659,0.00001832373,0.0001436355,0.0001954795,2.395276e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005208873,"about_ca_system_score_gemma":0.0002205352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004236465,"about_ca_topic_score_gemma":0.00001239057,"domain_scores_codex":[0.999074,0.00004754731,0.0002311115,0.0001357035,0.0003636337,0.0001479748],"domain_scores_gemma":[0.9989915,0.00001457036,0.000478564,0.0002521658,0.0001950723,0.0000681474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005112734,0.00006401985,0.0001214513,0.00001773158,0.00000588094,0.000001806634,0.0002975766,0.000003954607,0.9990237,0.0001563067,0.00002725325,0.0002292297],"study_design_scores_gemma":[0.0002604354,0.0006075877,0.0002690085,0.00006528631,0.000009970424,0.00009544624,0.0002113837,0.00002535487,0.9977188,0.0003156832,0.000364136,0.00005687616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998042,0.0002177221,0.0007389485,0.0003586677,0.0001105885,0.0001818887,0.000002460434,7.665914e-7,0.000346964],"genre_scores_gemma":[0.997991,0.0000139951,0.001702342,0.0000288102,0.0000789496,0.000001765498,1.58563e-7,0.000005863038,0.0001771762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00130483,"threshold_uncertainty_score":0.1879728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003812073751466952,"score_gpt":0.1997948071348714,"score_spread":0.1959827333834045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}