{"id":"W2113936882","doi":"10.1006/bbrc.2002.6607","title":"Metformin Effects on Dipeptidylpeptidase IV Degradation of Glucagon-like Peptide-1","year":2002,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Metformin; Glucagon-like peptide-1; Surface plasmon resonance; Chemistry; Dipeptidyl peptidase; Dipeptidyl peptidase-4; Internal medicine; Endocrinology; Hydrolysis; Peptide; Vildagliptin; Glycemic; Enzyme; Pharmacology; Biochemistry; Diabetes mellitus; Type 2 diabetes; Medicine; Nanoparticle; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002804472,0.0003695195,0.0004657424,0.0002303832,0.000268733,0.0004645329,0.0002144428,0.0003913157,0.003139375],"category_scores_gemma":[0.0005767348,0.0003617264,0.0004581235,0.0001557968,0.0003581052,0.0005056929,0.0002365017,0.000899978,0.0003879187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004813727,"about_ca_system_score_gemma":0.0006121511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372948,"about_ca_topic_score_gemma":0.001184736,"domain_scores_codex":[0.9998268,0.00004045645,0.00002055929,0.00002036613,0.00001812687,0.00007371563],"domain_scores_gemma":[0.9997043,0.00007568028,0.00006371697,0.00003649545,0.00002523081,0.00009443081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1462601,0.001320221,0.002922567,0.0002729222,0.0001251888,0.0005487623,0.00008480124,0.0005272275,0.8318009,0.000584167,0.0005566797,0.0149964],"study_design_scores_gemma":[0.002960854,0.01379186,0.02881982,0.00002824011,0.0002163287,0.0005348257,0.0002008544,0.001791204,0.9484001,0.0001788903,0.003041583,0.00003538988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970854,0.001706055,0.0002172642,0.00009352787,0.0001017914,0.00001378601,0.00015592,0.00002227553,0.0006039331],"genre_scores_gemma":[0.9969265,0.0007329594,0.0003925015,0.00004788919,0.0000216481,0.00002397049,0.0002795333,0.000009837385,0.00156513],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003139375,"threshold_uncertainty_score":0.01050228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08153660429434237,"score_gpt":0.3536752917050506,"score_spread":0.2721386874107082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}