{"id":"W2113936903","doi":"10.1093/toxsci/kfu103","title":"Extending an In Vitro Panel for Estrogenicity Testing: The Added Value of Bioassays for Measuring Antiandrogenic Activities and Effects on Steroidogenesis","year":2014,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"York University","keywords":"Reporter gene; In vivo; In vitro; Bioassay; Androgen receptor; Estrogen receptor; In vitro toxicology; Ligand binding assay; Chemistry; Estrogen; Biology; Pharmacology; Mechanism of action; Cell biology; Internal medicine; Receptor; Endocrinology; Biochemistry; Gene; Gene expression; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001561466,0.0001353688,0.0002263087,0.0000301568,0.0003239959,0.00004452666,0.0003349552,0.00005352731,0.000006348721],"category_scores_gemma":[0.001311775,0.00007443038,0.00006570025,0.0001957848,0.000571342,0.0001165686,0.0001154377,0.00006497702,6.017261e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003076242,"about_ca_system_score_gemma":0.000006889537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005863538,"about_ca_topic_score_gemma":0.0000153185,"domain_scores_codex":[0.9986725,0.0001536525,0.0001806281,0.0004022114,0.0002153107,0.0003756651],"domain_scores_gemma":[0.9958699,0.003819738,0.0001092161,0.0001196899,0.00000593635,0.00007546653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000659007,0.00009710043,0.01513714,0.00002579962,0.000003437708,4.17255e-7,0.00004667895,0.000560126,0.9509652,0.0002603006,0.000004776236,0.0328331],"study_design_scores_gemma":[0.0004371991,0.001389484,0.04311303,0.00002803448,0.00001690961,0.000004409592,0.00008120875,0.01636847,0.9363931,0.001990958,0.00003589741,0.0001412826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987553,0.00004412327,0.0002313205,0.0001353597,0.0000434394,0.000558364,0.000006473389,0.00002278617,0.0002028139],"genre_scores_gemma":[0.9938731,0.000004871409,0.005846654,0.0001333911,0.00003863538,0.00009318308,8.123877e-7,0.000005454751,0.000003926997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03269182,"threshold_uncertainty_score":0.3035183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07780356977925719,"score_gpt":0.3411578645390874,"score_spread":0.2633542947598302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}