{"id":"W2113964087","doi":"10.1093/hmg/ddq026","title":"Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression","year":2010,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Child and Family Research Institute","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Huntingtin; Internal medicine; Endocrinology; Biology; Insulin-like growth factor; Transgene; Genetically modified mouse; Growth factor; Mutant; Body weight; Receptor; Gene; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000680236,0.0002369769,0.0001683273,0.0002071927,0.00006567655,0.0002133541,0.0001190161,0.0001547095,0.0009429142],"category_scores_gemma":[0.0000840123,0.0001187851,0.0001391102,0.0001099407,0.0001839025,0.0001332626,0.0001001697,0.0004137626,0.0001189293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001850986,"about_ca_system_score_gemma":0.00008043479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004295011,"about_ca_topic_score_gemma":0.0008784751,"domain_scores_codex":[0.9999328,0.000008989666,0.000007259795,0.00001659383,0.0000180018,0.00001637237],"domain_scores_gemma":[0.9998842,0.00001734737,0.00004610316,0.00001021954,0.000008762289,0.00003320106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002140344,0.00001672975,0.0006442196,0.00001337854,0.000005778013,0.0000247793,0.000006446252,0.00001808969,0.9983776,0.00001416854,0.00001659224,0.0006482875],"study_design_scores_gemma":[0.00007361781,0.001275854,0.09841312,0.00001300707,0.00007547488,0.0003352032,0.00007924135,0.001283414,0.8970305,0.00009229719,0.001318077,0.00001027363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985003,0.0005891367,0.0003654501,0.00003050462,0.000007273216,0.000003949909,0.0001776612,0.00002855474,0.0002970791],"genre_scores_gemma":[0.9973781,0.0006272793,0.0006142927,0.00003809566,0.000005833718,0.00001883106,0.000298421,0.0000151545,0.001003945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009429142,"threshold_uncertainty_score":0.003154337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01996466268977943,"score_gpt":0.2623834070881155,"score_spread":0.2424187443983361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}