{"id":"W2113973956","doi":"10.1093/intimm/dxh254","title":"Immunosynapse formation coincides with rapid activation of NK cells by syngeneic T cells and correlates with clustering of MHC class I","year":2005,"lang":"en","type":"article","venue":"International Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"MHC restriction; Interleukin 21; CD1; Cell biology; Antigen-presenting cell; MHC class I; Ionomycin; Cytotoxic T cell; T cell; Major histocompatibility complex; ZAP70; Chemistry; Janus kinase 3; Interleukin 12; MHC class II; IL-2 receptor; Biology; Molecular biology; Antigen; CD8; Immunology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001316037,0.000193336,0.0002867526,0.0002454642,0.00008127905,0.00001371025,0.0001833579,0.0002091627,0.0007054345],"category_scores_gemma":[0.0000212518,0.0001583705,0.00004870457,0.00009803248,0.0003158348,0.0005408037,0.00007004128,0.0002687382,0.00006827628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000954198,"about_ca_system_score_gemma":0.00003381007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001419733,"about_ca_topic_score_gemma":0.00003501762,"domain_scores_codex":[0.99892,0.000106649,0.0004984274,0.0002147042,0.00006846051,0.0001917161],"domain_scores_gemma":[0.9987617,0.0001756792,0.0005595589,0.0001873923,0.0003050399,0.00001060867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001947816,0.0001681197,0.0002401314,0.00002434412,0.0005191717,5.504415e-7,0.0004910217,0.0004834443,0.9888802,0.0001753638,0.001481136,0.0055887],"study_design_scores_gemma":[0.002075412,0.0007722115,0.0007765976,0.0001267326,0.00004564213,0.0001736275,0.0006367989,0.0007409708,0.9688129,0.000007232157,0.02567052,0.0001613723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881582,0.001466202,0.006845818,0.0003455268,0.001129832,0.0002483766,0.00002540727,0.00004188585,0.001738738],"genre_scores_gemma":[0.9963172,0.0006754925,0.0002856185,0.00009958748,0.00001691531,0.00001979516,0.0002633798,0.00001931001,0.002302701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02418939,"threshold_uncertainty_score":0.7724013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005310044071566281,"score_gpt":0.1975574442451508,"score_spread":0.1922474001735845,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}