{"id":"W2113976730","doi":"10.1093/carcin/bgu235","title":"CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers—findings from two independent populations","year":2014,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto","funders":"National Institute on Drug Abuse; Ontario Ministry of Research and Innovation; Canadian Institutes of Health Research; National Cancer Institute; Vanderbilt-Ingram Cancer Center; Vanderbilt University","keywords":"Lung cancer; CYP2A6; Odds ratio; Medicine; Internal medicine; Population; Oncology; Demography; Biology; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009755447,0.0003740114,0.000596677,0.0004798362,0.0002364584,0.00003325298,0.0003458363,0.0002418078,0.0004646136],"category_scores_gemma":[0.0001077512,0.000412881,0.0001382844,0.0008476569,0.0002082758,0.0001486235,0.0001304592,0.0008307613,0.00002023103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003897146,"about_ca_system_score_gemma":0.0002101652,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02131549,"about_ca_topic_score_gemma":0.001863292,"domain_scores_codex":[0.9963064,0.001412111,0.0005300688,0.0007725293,0.0002703412,0.0007086],"domain_scores_gemma":[0.9987096,0.00016826,0.0003084424,0.0003719589,0.0001018064,0.0003399568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003169962,0.0001851312,0.6050676,0.000008494684,0.0001032849,0.0000118803,0.001109566,0.007400798,0.3615534,0.0000736307,0.0001068781,0.02406236],"study_design_scores_gemma":[0.002729408,0.00002311846,0.8165709,0.00001141747,0.0003617379,0.000004340691,0.0001491713,0.02758818,0.1508623,0.0002925445,0.0009970418,0.0004098811],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944396,0.001149886,0.0002017189,0.0005210895,0.002221706,0.0005564748,0.0003358767,0.00005677651,0.0005168729],"genre_scores_gemma":[0.9972848,0.001169621,0.0002529023,0.0002776278,0.0006183123,0.0002094166,0.00005439154,0.00005657888,0.00007632293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2115033,"threshold_uncertainty_score":0.9998323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08900709973242153,"score_gpt":0.4208992542085755,"score_spread":0.331892154476154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}