{"id":"W2113999479","doi":"10.1093/jac/dkt204","title":"The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites","year":2013,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mutation; Genetics; Biology; Virology; Single-nucleotide polymorphism; Thymidine; Nucleotide; Human immunodeficiency virus (HIV); Selection (genetic algorithm); Molecular biology; Genotype; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003195998,0.0002251639,0.0002683992,0.000190547,0.0001608276,0.0003166337,0.0002389073,0.0002640938,0.001168105],"category_scores_gemma":[0.0004684507,0.0001281996,0.0002142692,0.0001616016,0.0001863462,0.0001134093,0.000170449,0.000293821,0.0003883809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001417125,"about_ca_system_score_gemma":0.0001905697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006317264,"about_ca_topic_score_gemma":0.0007997818,"domain_scores_codex":[0.9996697,0.00008554313,0.00004487706,0.00005895334,0.00007551329,0.0000653465],"domain_scores_gemma":[0.9995911,0.0001141309,0.0001496167,0.0000519795,0.00004738948,0.00004578189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001359424,0.00002229577,0.001921294,0.00003794867,0.000009044709,0.0001031556,0.00001589882,0.00004367973,0.9956506,0.00003129799,0.00001424161,0.002014744],"study_design_scores_gemma":[0.00004817035,0.001612599,0.05017775,0.00002766988,0.00006989015,0.002737119,0.00007752383,0.001190152,0.9420711,0.00006790843,0.001904716,0.00001549776],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975427,0.0008015789,0.0008431817,0.00002259809,0.000005997923,0.00001519733,0.00005654134,0.00001789674,0.0006944064],"genre_scores_gemma":[0.9985515,0.0002841804,0.0007927246,0.00003273928,0.00000482619,0.000008964004,0.00007922503,0.000008733369,0.0002370224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168105,"threshold_uncertainty_score":0.003907681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008312833761768263,"score_gpt":0.2321000532562385,"score_spread":0.2237872194944702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}