{"id":"W2113999582","doi":"10.1101/gad.247940.114","title":"Nascent RNA interaction keeps PRC2 activity poised and in check","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; New York State Stem Cell Science; York University; Howard Hughes Medical Institute","keywords":"PRC2; Biology; Chromatin; Histone H3; Transcription (linguistics); Cell biology; Psychological repression; Repressor; RNA; Histone; Genetics; Gene; Transcription factor; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002458498,0.0001093398,0.0000943093,0.00004635651,0.000047922,0.00001968259,0.00005516632,0.0000847688,0.00000638542],"category_scores_gemma":[0.00002946875,0.0001090959,0.00001956984,0.00004667962,0.00001575377,0.000003622917,0.00007884522,0.00004986189,0.000006369159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003071274,"about_ca_system_score_gemma":0.00005022237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001529485,"about_ca_topic_score_gemma":0.0001740017,"domain_scores_codex":[0.9992859,0.00005199563,0.0001539812,0.0002625162,0.00009023413,0.0001553877],"domain_scores_gemma":[0.999711,0.000007788602,0.00005862516,0.0001348266,0.00003343759,0.00005426363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004404477,0.00003741503,0.01032495,0.00001052403,0.00001160773,3.416424e-7,0.00009993747,0.00005085294,0.811098,0.000005402109,0.00002396984,0.1782929],"study_design_scores_gemma":[0.000301653,0.00004620536,0.1890889,0.0000100869,0.000002190999,8.201699e-7,0.00001872686,0.0001344991,0.7440299,0.00002858588,0.06621344,0.0001249968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954861,0.0006519905,0.002900181,0.00009490994,0.000166499,0.0001269923,5.601364e-7,0.00000680361,0.0005659009],"genre_scores_gemma":[0.9966359,0.0006543658,0.002373137,0.00006124608,0.00007728236,0.00002337152,0.00003045981,0.00001174995,0.0001324942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1787639,"threshold_uncertainty_score":0.4448802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111628171790311,"score_gpt":0.2528866887434462,"score_spread":0.2417238715644151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}