{"id":"W2113999582","doi":"10.1101/gad.247940.114","title":"Nascent RNA interaction keeps PRC2 activity poised and in check","year":2014,"lang":"en","type":"article","venue":"Genes & Development","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":210,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; New York State Stem Cell Science; York University; Howard Hughes Medical Institute","keywords":"PRC2; Biology; Chromatin; Histone H3; Transcription (linguistics); Cell biology; Psychological repression; Repressor; RNA; Histone; Genetics; Gene; Transcription factor; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002513236,0.0002815481,0.0003510614,0.0001133656,0.0003856292,0.001017229,0.000307834,0.0003451882,0.002443516],"category_scores_gemma":[0.0003831212,0.0002967952,0.0002708556,0.0001011463,0.0003725743,0.0005126071,0.0006451277,0.0008201876,0.001437068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006231077,"about_ca_system_score_gemma":0.0004682533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005208456,"about_ca_topic_score_gemma":0.001263488,"domain_scores_codex":[0.9995709,0.00003265067,0.00002632648,0.000185931,0.0001254313,0.00005867941],"domain_scores_gemma":[0.9996647,0.00005775526,0.00005263317,0.00009524458,0.00005571298,0.00007385284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003078463,0.000004186807,0.0003165073,0.00001282362,0.000004045219,0.00003805932,0.00001583414,0.00004077297,0.9979837,0.0003797867,0.00004095427,0.001132533],"study_design_scores_gemma":[0.000008414185,0.00006099635,0.003254945,0.00000361221,0.000008697921,0.000175342,0.00002603236,0.0007779727,0.9896826,0.0001550793,0.005840681,0.000005584727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776169,0.001726452,0.01272638,0.0002615055,0.000142042,0.00001389706,0.0003704192,0.0003362149,0.006806236],"genre_scores_gemma":[0.9875059,0.0003669424,0.00297151,0.00008974396,0.00003017725,0.00001311265,0.0006141049,0.00009765185,0.008310848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002443516,"threshold_uncertainty_score":0.008174419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111628171790311,"score_gpt":0.2528866887434462,"score_spread":0.2417238715644151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}