{"id":"W2114001485","doi":"10.2337/db13-0128","title":"Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes","year":2013,"lang":"en","type":"review","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; McGill University; Jewish General Hospital","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; Canadian Institutes of Health Research; Fogarty International Center; National Heart, Lung, and Blood Institute; Sahlgrenska Akademin; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome Trust; Biotechnology and Biological Sciences Research Council; National Institute of Environmental Health Sciences; School of Medicine, Stanford University; Università di Pisa; National Institutes of Health; Syddansk Universitet; National Institute of Nursing Research; Novo Nordisk Foundation Center for Basic Metabolic Research; National Institute for Health and Care Research; Novo Nordisk; Eberhard Karls Universität Tübingen; National Human Genome Research Institute; University of Oxford; University of Dundee; National Center for Advancing Translational Sciences; Medical Research Council; Joslin Diabetes Center; School of Medicine, Boston University","keywords":"Mendelian randomization; Adiponectin; Insulin resistance; Type 2 diabetes; Internal medicine; Medicine; Diabetes mellitus; Endocrinology; Randomization; Insulin; Clinical trial; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05545562,0.001169533,0.003024139,0.00138721,0.000656421,0.001477975,0.001825783,0.00164876,0.003865315],"category_scores_gemma":[0.137734,0.0006706531,0.002334189,0.001957355,0.003672746,0.00130975,0.0008975728,0.001614029,0.0004694946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006336983,"about_ca_system_score_gemma":0.0009470072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001128753,"about_ca_topic_score_gemma":0.001104692,"domain_scores_codex":[0.9260026,0.0557728,0.002971187,0.008023102,0.006549211,0.0006809955],"domain_scores_gemma":[0.8623918,0.1034024,0.01522378,0.01638057,0.001950724,0.0006506921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.02694185,0.0006326392,0.6333851,0.002874478,0.07008435,0.005061604,0.001290686,0.008548587,0.007593089,0.07535665,0.006790685,0.1614404],"study_design_scores_gemma":[0.02340183,0.01048038,0.4838787,0.00172559,0.04130727,0.0150931,0.0008148318,0.09160537,0.007551027,0.2927358,0.03082921,0.0005768558],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6762482,0.02871576,0.2693239,0.006901675,0.002558653,0.00125899,0.001497809,0.001594353,0.01190063],"genre_scores_gemma":[0.9631755,0.002405165,0.02992334,0.002608975,0.0004750424,0.0003261566,0.0004288275,0.000111293,0.0005457605],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.05545562,"threshold_uncertainty_score":0.2932808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05649872616490051,"score_gpt":0.3393064301366437,"score_spread":0.2828077039717432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}