{"id":"W2114001485","doi":"10.2337/db13-0128","title":"Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes","year":2013,"lang":"en","type":"review","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke; McGill University; Jewish General Hospital","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; Canadian Institutes of Health Research; Fogarty International Center; National Heart, Lung, and Blood Institute; Sahlgrenska Akademin; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; National Institute of Diabetes and Digestive and Kidney Diseases; Wellcome Trust; Biotechnology and Biological Sciences Research Council; National Institute of Environmental Health Sciences; School of Medicine, Stanford University; Università di Pisa; National Institutes of Health; Syddansk Universitet; National Institute of Nursing Research; Novo Nordisk Foundation Center for Basic Metabolic Research; National Institute for Health and Care Research; Novo Nordisk; Eberhard Karls Universität Tübingen; National Human Genome Research Institute; University of Oxford; University of Dundee; National Center for Advancing Translational Sciences; Medical Research Council; Joslin Diabetes Center; School of Medicine, Boston University","keywords":"Mendelian randomization; Adiponectin; Insulin resistance; Type 2 diabetes; Internal medicine; Medicine; Diabetes mellitus; Endocrinology; Randomization; Insulin; Clinical trial; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009908163,0.000349296,0.001361378,0.0001245705,0.0001052207,0.00003273174,0.0001392247,0.0004458594,0.000008954179],"category_scores_gemma":[0.002776074,0.0003062083,0.0001701614,0.0001769548,0.00006900055,0.000005861352,0.0001074915,0.0001347247,0.000005231926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005305328,"about_ca_system_score_gemma":0.0001588412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003513678,"about_ca_topic_score_gemma":0.00001881569,"domain_scores_codex":[0.997791,0.0003373991,0.0007447302,0.0005919106,0.00007770459,0.0004572801],"domain_scores_gemma":[0.9986135,0.0003723808,0.0004736863,0.0002694263,0.0002068893,0.00006411943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006612109,0.0001229048,0.007702786,0.01161676,0.00253846,0.000001411746,0.0004144448,0.00007193302,0.02694391,0.000129108,0.006173401,0.9442188],"study_design_scores_gemma":[0.004991103,0.0005744103,0.003042198,0.004224438,0.001328014,0.000002295938,0.0003458434,0.0002983506,0.003495158,0.001028908,0.9788067,0.001862549],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.140455,0.8581449,0.00001171847,0.00005105306,0.0001787211,0.0009886092,0.0001056401,0.00001004383,0.00005428175],"genre_scores_gemma":[0.04724663,0.9480968,0.002252856,0.00009216848,0.000252155,0.0008578897,0.000769428,0.00006492352,0.000367128],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9726333,"threshold_uncertainty_score":0.999939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05649872616490051,"score_gpt":0.3393064301366437,"score_spread":0.2828077039717432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}