{"id":"W2114005632","doi":"10.1128/iai.70.8.4669-4677.2002","title":"<i>Escherichia coli</i> Shiga-Like Toxins Induce Apoptosis and Cleavage of Poly(ADP-Ribose) Polymerase via In Vitro Activation of Caspases","year":2002,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Health Canada; Hospital for Sick Children","funders":"","keywords":"Apoptosis; Shiga toxin; Biology; Molecular biology; Poly ADP ribose polymerase; DNA fragmentation; Acridine orange; Programmed cell death; Shiga-like toxin; Biochemistry; Escherichia coli; Polymerase; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025791,0.0006084922,0.0003009943,0.0002245212,0.0001038218,0.0002945342,0.0001559914,0.0002696837,0.001225608],"category_scores_gemma":[0.0002251839,0.0001510836,0.0003867791,0.0002320711,0.0001795133,0.0001582769,0.000157641,0.0004819735,0.0006069061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003614494,"about_ca_system_score_gemma":0.0001765201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000445755,"about_ca_topic_score_gemma":0.0005897937,"domain_scores_codex":[0.9996622,0.0001111996,0.00004401557,0.0000335399,0.00007326207,0.0000758424],"domain_scores_gemma":[0.9998443,0.00004103974,0.00004141289,0.00002777436,0.00002722043,0.00001826603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001336643,0.00003538403,0.0001894188,0.00005255543,0.000008394894,0.00005205248,0.000007228905,0.00007130428,0.9984471,0.00008148363,0.0001228347,0.0007985843],"study_design_scores_gemma":[0.00001573677,0.0002505966,0.002725525,0.000008272869,0.000007565088,0.0002259904,0.000009486122,0.0006785163,0.9945986,0.00003197535,0.001444805,0.00000284282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776638,0.00366634,0.01094864,0.0002615323,0.0001359589,0.0001390346,0.0014582,0.0003384038,0.005387894],"genre_scores_gemma":[0.9808883,0.001948733,0.007736495,0.0001975844,0.00004008142,0.000107059,0.004929441,0.00004278853,0.004109474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225608,"threshold_uncertainty_score":0.004100084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179390173717698,"score_gpt":0.2211373557474068,"score_spread":0.2093434540102299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}