{"id":"W2114005632","doi":"10.1128/iai.70.8.4669-4677.2002","title":"<i>Escherichia coli</i> Shiga-Like Toxins Induce Apoptosis and Cleavage of Poly(ADP-Ribose) Polymerase via In Vitro Activation of Caspases","year":2002,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Health Canada; Hospital for Sick Children","funders":"","keywords":"Apoptosis; Shiga toxin; Biology; Molecular biology; Poly ADP ribose polymerase; DNA fragmentation; Acridine orange; Programmed cell death; Shiga-like toxin; Biochemistry; Escherichia coli; Polymerase; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001001171,0.00009228064,0.000127118,0.00007252311,0.00006320191,0.000007865375,0.00002682263,0.0001318365,0.00001201687],"category_scores_gemma":[0.00002172357,0.00009195903,0.00003282019,0.0001274535,0.00006072283,0.00001366992,0.00004236214,0.0000841149,2.734159e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008403993,"about_ca_system_score_gemma":0.000008744878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625072,"about_ca_topic_score_gemma":0.00004773857,"domain_scores_codex":[0.9994733,0.00007826281,0.000181328,0.000122904,0.00005650509,0.00008771172],"domain_scores_gemma":[0.99967,0.00001341764,0.0001091377,0.0001368835,0.00003634863,0.00003420586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008989678,0.0001506306,0.001167158,0.00002962648,0.00001519262,8.68754e-8,0.0001142814,0.00000342356,0.9799812,0.00001431256,0.00002856404,0.01840566],"study_design_scores_gemma":[0.0004942528,0.0002453017,0.02774412,0.00001569684,0.00001176959,0.000003467358,0.00005504242,0.0002151451,0.9705058,0.00001632739,0.0006036898,0.00008933069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981219,0.0004676675,0.0008543025,0.00003830238,0.00007784865,0.0001133796,0.000008236884,0.00000554122,0.0003128207],"genre_scores_gemma":[0.9989057,0.0007748529,0.00009252968,0.00007527888,0.0000309565,0.000005265008,0.00003773654,0.000008007685,0.0000696381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02657696,"threshold_uncertainty_score":0.374998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179390173717698,"score_gpt":0.2211373557474068,"score_spread":0.2093434540102299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}