{"id":"W2114007508","doi":"10.1093/toxsci/kfi203","title":"Effects of Atrazine on CYP19 Gene Expression and Aromatase Activity in Testes and on Plasma Sex Steroid Concentrations of Male African Clawed Frogs (Xenopus laevis)","year":2005,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Environmental Health Sciences; College of Engineering, Michigan State University; Michigan State University","keywords":"Aromatase; Xenopus; Internal medicine; Endocrinology; Atrazine; Biology; Testosterone (patch); Gene expression; Sex steroid; African clawed frog; Gonad; Steroid; Gene; Hormone; Biochemistry; Pesticide; Ecology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003858758,0.0001605533,0.0002947567,0.00005459613,0.0001822186,0.00001270605,0.0001953316,0.0001627334,0.0005446873],"category_scores_gemma":[0.0001229,0.0001163065,0.0000263522,0.0002186111,0.001958395,0.0001858173,0.0001912384,0.0001587786,0.00001881619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007519781,"about_ca_system_score_gemma":0.000006872266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001511551,"about_ca_topic_score_gemma":0.0001050022,"domain_scores_codex":[0.9985327,0.0002196464,0.0002424733,0.0004659125,0.0002258613,0.0003134568],"domain_scores_gemma":[0.998708,0.0009009751,0.0001496972,0.0001156644,0.000001408148,0.000124275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001093462,0.0008380371,0.09272216,0.00001017667,0.000002688463,0.000009254168,0.000133553,0.001054301,0.9023181,0.00008261603,0.00005052385,0.002669278],"study_design_scores_gemma":[0.0005843093,0.002201113,0.2866318,0.0000174625,0.000005870565,0.000008259589,0.00004691057,0.0005540745,0.7096123,0.0001421739,0.0000934853,0.0001022154],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963265,0.00004934395,0.000005752961,0.0003630371,0.00003034086,0.0004017569,0.00001670326,0.0000106359,0.002795936],"genre_scores_gemma":[0.998441,0.00009124689,0.001067636,0.0002335739,0.00001298997,0.00003263933,0.000001438555,0.0000034765,0.0001159512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1939097,"threshold_uncertainty_score":0.7215788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01406180190123558,"score_gpt":0.2430986974310832,"score_spread":0.2290368955298476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}