{"id":"W2114018465","doi":"10.2217/17435889.2.3.375","title":"Mimicking Nature‘S Nanocarrier: Synthetic Low-Density Lipoprotein-Like Nanoparticles for Cancer-Drug Delivery","year":2007,"lang":"en","type":"letter","venue":"Nanomedicine","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Nanocarriers; Drug delivery; Nanotechnology; Nanoparticle; Drug; Targeted drug delivery; Low-density lipoprotein; Materials science; Chemistry; Pharmacology; Medicine; Cholesterol; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000586755,0.0006449534,0.0008480138,0.000211943,0.0002200618,0.00003657345,0.0005266758,0.00170212,0.00006788671],"category_scores_gemma":[0.0001618167,0.0005883614,0.0003942867,0.0001863691,0.000339542,0.000007024868,0.0001642806,0.001220566,0.00001025044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001289988,"about_ca_system_score_gemma":0.0004986337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405601,"about_ca_topic_score_gemma":0.0007290186,"domain_scores_codex":[0.9965845,0.00008083452,0.0006028602,0.001121301,0.0005329812,0.001077463],"domain_scores_gemma":[0.9980448,0.00007894223,0.0003574458,0.0009105924,0.0003950156,0.0002131576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001906918,0.00002476172,0.00002733442,0.0003758995,0.0001621721,0.000005953637,0.00005808791,0.000002060809,0.2787651,0.000002605571,0.7049419,0.01544335],"study_design_scores_gemma":[0.001183428,0.0001428321,0.00008464214,0.0003610555,0.0002826276,0.00003831726,0.00003581878,0.000004695244,0.1768558,0.00002795664,0.8204333,0.0005495566],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5556045,0.1470077,0.000410788,0.1876619,0.1038534,0.00365182,0.001154031,0.0001902694,0.0004655813],"genre_scores_gemma":[0.05992201,0.006588035,0.0006205239,0.6628112,0.2579676,0.0004621249,0.001474411,0.0003113946,0.009842677],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4956825,"threshold_uncertainty_score":0.9996568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0080963283281021,"score_gpt":0.2512720196633176,"score_spread":0.2431756913352155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}